PMID- 22192600
OWN - NLM
STAT- MEDLINE
DCOM- 20120709
LR  - 20191210
IS  - 1365-2826 (Electronic)
IS  - 0953-8194 (Linking)
VI  - 24
IP  - 5
DP  - 2012 May
TI  - Early levothyroxine treatment on maternal subclinical hypothyroidism improves 
      spatial learning of offspring in rats.
PG  - 841-8
LID - 10.1111/j.1365-2826.2011.02275.x [doi]
AB  - Maternal hypothyroidism has adverse effects on neural development in the 
      offspring. The present study aimed to investigate whether maternal subclinical 
      hypothyroidism impairs spatial learning in the offspring, as well as the efficacy 
      and optimal time of levothyroxine (L-T(4)) treatment in pregnancy. Female adult 
      Wistar rats were randomly divided into six groups (n = 10 per group): control, 
      hypothyroid (H), subclinical hypothyroid (SCH) and SCH treated with L-T(4), 
      starting from the tenth, thirteenth and seventeenth gestational day (GD10, GD13 
      and GD17), respectively, to restore normal thyroid hormone levels. Spatial 
      learning was assessed on progenies by a water maze test, a field excitatory 
      postsynaptic potential (fEPSP) recording, and an long-term potentiation induction 
      assay. Protein levels of early growth response protein 1 (Egr1), 
      activity-regulated cytoskeleton-associated protein (Arc), Ras-proximate-1 (Rap1), 
      p-extracellular signal-regulated kinase (p-ERK) and brain-derived neurotrophic 
      factor (BDNF) were determined by western blotting. Progenies from the SCH and H 
      groups demonstrated significantly longer mean latency in the water maze test and 
      a lower amplification percentage of the amplitude and slope of the fEPSPs 
      compared to offspring of the control group. L-T(4) treatment for the GD10 and 
      GD13 groups significantly shortened mean latency and increased the amplification 
      percentage of the amplitude and slope of the fEPSPs of the progeny of rats with 
      subclinical hypothyroidism. However, L-T(4) treatment for the GD17 group showed 
      only minimal effects on spatial learning in the offspring. Progenies of SCH and H 
      groups had lower levels of Egr1, Arc, p-ERK and BDNF but higher levels of Rap1 
      compared to those of the controls. L-T(4) treatment ameliorated these protein 
      expression changes in the progeny of rats with subclinical hypothyroidism. 
      Maternal subclinical hypothyroidism impaired spatial learning in the offspring; 
      L-T(4) treatment in early pregnancy recovered this adverse effect, and the 
      optimal time of treatment should start from early pregnancy (GD10 and GD13).
CI  - (c) 2011 The Authors. Journal of Neuroendocrinology (c) 2011 Blackwell Publishing 
      Ltd.
FAU - Wang, S
AU  - Wang S
AD  - Department of Endocrinology and Metabolism, The First Hospital of China Medical 
      University, Shenyang, China.
FAU - Teng, W
AU  - Teng W
FAU - Gao, Y
AU  - Gao Y
FAU - Fan, C
AU  - Fan C
FAU - Zhang, H
AU  - Zhang H
FAU - Shan, Z
AU  - Shan Z
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Asymptomatic Diseases
MH  - Congenital Hypothyroidism/physiopathology/*prevention & control/psychology
MH  - Female
MH  - Hypothyroidism/*drug therapy/pathology/physiopathology/psychology
MH  - Learning/*drug effects/physiology
MH  - Maze Learning/drug effects/physiology
MH  - Pregnancy
MH  - Pregnancy Complications/drug therapy/pathology
MH  - Prenatal Care/methods
MH  - Rats
MH  - Rats, Wistar
MH  - Spatial Behavior/*drug effects
MH  - Thyroxine/*administration & dosage/pharmacology
EDAT- 2011/12/24 06:00
MHDA- 2012/07/10 06:00
CRDT- 2011/12/24 06:00
PHST- 2011/12/24 06:00 [entrez]
PHST- 2011/12/24 06:00 [pubmed]
PHST- 2012/07/10 06:00 [medline]
AID - 10.1111/j.1365-2826.2011.02275.x [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2012 May;24(5):841-8. doi: 10.1111/j.1365-2826.2011.02275.x.