PMID- 22194166
OWN - NLM
STAT- MEDLINE
DCOM- 20120606
LR  - 20221207
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 10
IP  - 4
DP  - 2011 Dec 15
TI  - Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis.
PG  - 3109-20
LID - 10.4238/2011.December.15.2 [doi]
AB  - Numerous studies have evaluated the association between human leukocyte antigen 
      (HLA) Cw*0602 polymorphism and psoriasis risk. However, the results have been 
      inconsistent. We made a meta-analysis of the association between HLA-Cw*0602 
      polymorphism and psoriasis risk. Eighteen studies were retrieved, reporting a 
      total of 3419 psoriasis patients and 3297 healthy controls. The associations 
      between HLA-Cw*0602 polymorphism and psoriasis risk were estimated by pooled odds 
      ratio (OR) and 95% confidence interval (95%CI). We found significant associations 
      between HLA-Cw*0602 polymorphism and psoriasis risk in the comparisons of 
      positive versus negative alleles (OR = 4.55, 95%CI = 3.65-5.67, P < 0.00001); 
      positive homozygote versus negative homozygote combined with heterozygote (OR = 
      14.00, 95%CI = 8.47-23.15, P < 0.00001); positive homozygote combined with 
      heterozygote versus negative homozygote (OR = 5.11, 95%CI = 3.86-6.76, P < 
      0.00001); positive homozygote versus negative homozygote (OR = 23.03, 95%CI = 
      13.95-38.00, P < 0.00001), and positive homozygote versus heterozygote (OR = 
      4.21, 95%CI = 2.35- 7.00, P < 0.00001). In conclusion, the positive allele of 
      HLA-Cw*0602 polymorphism appears to be a risk factor for psoriasis.
FAU - Wu, D
AU  - Wu D
AD  - Department of Dermatology, Beihua Affiliated Hospital, Jilin, China.
FAU - Wu, Y
AU  - Wu Y
FAU - Liu, J L
AU  - Liu JL
FAU - Wang, B
AU  - Wang B
FAU - Zhang, X D
AU  - Zhang XD
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20111215
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - *Asian People
MH  - Case-Control Studies
MH  - Databases, Bibliographic
MH  - Female
MH  - Gene Frequency
MH  - Genetic Linkage
MH  - Genetic Predisposition to Disease
MH  - HLA-C Antigens/*genetics
MH  - Heterozygote
MH  - Homozygote
MH  - Humans
MH  - Male
MH  - Odds Ratio
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Psoriasis/*genetics
MH  - Risk
MH  - *White People
EDAT- 2011/12/24 06:00
MHDA- 2012/06/07 06:00
CRDT- 2011/12/24 06:00
PHST- 2011/12/24 06:00 [entrez]
PHST- 2011/12/24 06:00 [pubmed]
PHST- 2012/06/07 06:00 [medline]
AID - gmr1259 [pii]
AID - 10.4238/2011.December.15.2 [doi]
PST - epublish
SO  - Genet Mol Res. 2011 Dec 15;10(4):3109-20. doi: 10.4238/2011.December.15.2.