PMID- 22194960
OWN - NLM
STAT- MEDLINE
DCOM- 20120827
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 12
DP  - 2011
TI  - Immunoglobulin E and mast cell proteases are potential risk factors of human 
      pre-diabetes and diabetes mellitus.
PG  - e28962
LID - 10.1371/journal.pone.0028962 [doi]
LID - e28962
AB  - BACKGROUND: Recent studies have suggested that mast-cell activation and 
      inflammation are important in obesity and diabetes. Plasma levels of mast cell 
      proteases and the mast cell activator immunoglobulin E (IgE) may serve as novel 
      inflammatory markers that associate with the risk of pre-diabetes and diabetes 
      mellitus. METHODS AND RESULTS: A total of 340 subjects 55 to 75 years of age were 
      grouped according to the American Diabetes Association 2003 criteria of normal 
      glucose tolerance, pre-diabetes, and diabetes mellitus. The Kruskal-Wallis test 
      demonstrated significant differences in plasma IgE levels (P = 0.008) among 
      groups with different glucose tolerance status. Linear regression analysis 
      revealed significant correlations between plasma levels of chymase (P = 0.030) or 
      IgE (P = 0.022) and diabetes mellitus. Ordinal logistic regression analysis 
      showed that IgE was a significant risk factor of pre-diabetes and diabetes 
      mellitus (odds ratio [OR]: 1.674, P = 0.034). After adjustment for common 
      diabetes risk factors, including age, sex, hypertension, body-mass index, 
      cholesterol, homeostatic model assessment (HOMA) index, high-sensitivity 
      C-reactive protein (hs-CRP), and mast cell chymase and tryptase, IgE remained a 
      significant risk factor (OR: 1.866, P = 0.015). Two-variable ordinal logistic 
      analysis indicated that interactions between hs-CRP and IgE, or between IgE and 
      chymase, increased further the risks of developing pre-diabetes and diabetes 
      mellitus before (OR: 2.204, P = 0.044; OR: 2.479, P = 0.033) and after (OR: 
      2.251, P = 0.040; OR: 2.594, P = 0.026) adjustment for common diabetes risk 
      factors. CONCLUSIONS: Both IgE and chymase associate with diabetes status. While 
      IgE and hs-CRP are individual risk factors of pre-diabetes and diabetes mellitus, 
      interactions of IgE with hs-CRP or with chymase further increased the risk of 
      pre-diabetes and diabetes mellitus.
FAU - Wang, Zhen
AU  - Wang Z
AD  - Department of Clinical Medicine, School of Medicine, Huzhou Teachers College, 
      Huzhou, Zhejiang, China.
FAU - Zhang, Hong
AU  - Zhang H
FAU - Shen, Xu-Hui
AU  - Shen XH
FAU - Jin, Kui-Li
AU  - Jin KL
FAU - Ye, Guo-fen
AU  - Ye GF
FAU - Qian, Li
AU  - Qian L
FAU - Li, Bo
AU  - Li B
FAU - Zhang, Yong-Hong
AU  - Zhang YH
FAU - Shi, Guo-Ping
AU  - Shi GP
LA  - eng
GR  - R01 HL088547/HL/NHLBI NIH HHS/United States
GR  - HL60942/HL/NHLBI NIH HHS/United States
GR  - HL88547/HL/NHLBI NIH HHS/United States
GR  - R01 HL081090/HL/NHLBI NIH HHS/United States
GR  - R01 HL060942/HL/NHLBI NIH HHS/United States
GR  - HL81090/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111216
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.21.39 (Chymases)
RN  - EC 3.4.21.59 (Tryptases)
SB  - IM
MH  - Aged
MH  - Anthropometry
MH  - C-Reactive Protein/metabolism
MH  - Chymases/*blood/metabolism
MH  - Diabetes Mellitus/*blood/*enzymology/immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Logistic Models
MH  - Male
MH  - Mast Cells/enzymology
MH  - Middle Aged
MH  - Prediabetic State/*blood/*enzymology/immunology
MH  - Risk Factors
MH  - Tryptases/*blood/metabolism
PMC - PMC3241693
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2011/12/24 06:00
MHDA- 2012/08/28 06:00
PMCR- 2011/12/16
CRDT- 2011/12/24 06:00
PHST- 2011/07/13 00:00 [received]
PHST- 2011/11/17 00:00 [accepted]
PHST- 2011/12/24 06:00 [entrez]
PHST- 2011/12/24 06:00 [pubmed]
PHST- 2012/08/28 06:00 [medline]
PHST- 2011/12/16 00:00 [pmc-release]
AID - PONE-D-11-13315 [pii]
AID - 10.1371/journal.pone.0028962 [doi]
PST - ppublish
SO  - PLoS One. 2011;6(12):e28962. doi: 10.1371/journal.pone.0028962. Epub 2011 Dec 16.