PMID- 22197092
OWN - NLM
STAT- MEDLINE
DCOM- 20130124
LR  - 20130404
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 81
IP  - 10
DP  - 2012 Oct
TI  - The size does not matter - the presence of microvascular obstruction but not its 
      extent corresponds to larger infarct size in reperfused STEMI.
PG  - 2839-43
LID - 10.1016/j.ejrad.2011.11.053 [doi]
AB  - BACKGROUND: Microvascular obstruction (MVO) is a cardiac magnetic resonance (CMR) 
      marker of no-reflow in ST-segment elevation myocardial infarction (STEMI). It 
      remains unresolved whether the infarct size corresponds only to the presence of 
      MVO or also to its extent. METHODS: The study included 53 patients with first 
      STEMI (median age 61.5 years, 77% male) treated with percutaneous coronary 
      intervention (PCI) who underwent CMR after median 5 days from PCI. Small MVO was 
      defined as patchy, non-confluent spots of dark areas of absent contrast 
      surrounded by late gadolinium enhancement (LGE). Large MVO was defined as 
      confluent areas of MVO comprising a large amount of the infarct zone. RESULTS: 
      Microvascular obstruction was observed in 32 patients (60%) including 18 patients 
      with small MVO (36%) and 14 patients with large MVO (24%). Patients with MVO were 
      more likely to have TIMI 0/1 grade flow on initial angiogram, higher levels of 
      necrotic markers, larger infarct size, larger left ventricular end-diastolic and 
      end-systolic volume and lower ejection fraction in comparison to patients without 
      MVO. These differences were not observed between patients with large and small 
      MVO. CONCLUSIONS: The presence of MVO but not its extent corresponds to larger 
      infarct size in STEMI.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Malek, Lukasz A
AU  - Malek LA
AD  - Department of Interventional Cardiology and Angiology, Institute of Cardiology, 
      Warsaw, Poland. lmalek@ikard.pl
FAU - Spiewak, Mateusz
AU  - Spiewak M
FAU - Klopotowski, Mariusz
AU  - Klopotowski M
FAU - Misko, Jolanta
AU  - Misko J
FAU - Ruzyllo, Witold
AU  - Ruzyllo W
FAU - Witkowski, Adam
AU  - Witkowski A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111223
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
CIN - Rofo. 2013 Mar;185(3):201. PMID: 23565510
MH  - Aged
MH  - Constriction, Pathologic/pathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Angiography/*methods
MH  - Male
MH  - Microvessels/*pathology
MH  - Middle Aged
MH  - Myocardial Infarction/*pathology/*surgery
MH  - *Percutaneous Coronary Intervention
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - *Severity of Illness Index
MH  - Treatment Outcome
EDAT- 2011/12/27 06:00
MHDA- 2013/01/25 06:00
CRDT- 2011/12/27 06:00
PHST- 2011/09/20 00:00 [received]
PHST- 2011/11/28 00:00 [revised]
PHST- 2011/11/30 00:00 [accepted]
PHST- 2011/12/27 06:00 [entrez]
PHST- 2011/12/27 06:00 [pubmed]
PHST- 2013/01/25 06:00 [medline]
AID - S0720-048X(11)00831-X [pii]
AID - 10.1016/j.ejrad.2011.11.053 [doi]
PST - ppublish
SO  - Eur J Radiol. 2012 Oct;81(10):2839-43. doi: 10.1016/j.ejrad.2011.11.053. Epub 
      2011 Dec 23.