PMID- 22197856
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20220419
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Linking)
VI  - 54
IP  - 1
DP  - 2012 Jan
TI  - European Society for Pediatric Gastroenterology, Hepatology, and Nutrition 
      guidelines for the diagnosis of coeliac disease.
PG  - 136-60
LID - 10.1097/MPG.0b013e31821a23d0 [doi]
AB  - OBJECTIVE: Diagnostic criteria for coeliac disease (CD) from the European Society 
      for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) were 
      published in 1990. Since then, the autoantigen in CD, tissue transglutaminase, 
      has been identified; the perception of CD has changed from that of a rather 
      uncommon enteropathy to a common multiorgan disease strongly dependent on the 
      haplotypes human leukocyte antigen (HLA)-DQ2 and HLA-DQ8; and CD-specific 
      antibody tests have improved. METHODS: A panel of 17 experts defined CD and 
      developed new diagnostic criteria based on the Delphi process. Two groups of 
      patients were defined with different diagnostic approaches to diagnose CD: 
      children with symptoms suggestive of CD (group 1) and asymptomatic children at 
      increased risk for CD (group 2). The 2004 National Institutes of Health/Agency 
      for Healthcare Research and Quality report and a systematic literature search on 
      antibody tests for CD in paediatric patients covering the years 2004 to 2009 was 
      the basis for the evidence-based recommendations on CD-specific antibody testing. 
      RESULTS: In group 1, the diagnosis of CD is based on symptoms, positive serology, 
      and histology that is consistent with CD. If immunoglobulin A anti-tissue 
      transglutaminase type 2 antibody titers are high (>10 times the upper limit of 
      normal), then the option is to diagnose CD without duodenal biopsies by applying 
      a strict protocol with further laboratory tests. In group 2, the diagnosis of CD 
      is based on positive serology and histology. HLA-DQ2 and HLA-DQ8 testing is 
      valuable because CD is unlikely if both haplotypes are negative. CONCLUSIONS: The 
      aim of the new guidelines was to achieve a high diagnostic accuracy and to reduce 
      the burden for patients and their families. The performance of these guidelines 
      in clinical practice should be evaluated prospectively.
FAU - Husby, S
AU  - Husby S
AD  - Hans Christian Andersen Children's Hospital at Odense University Hospital. 
      steffen.husby@ouh.regionsyddanmark.dk
FAU - Koletzko, S
AU  - Koletzko S
FAU - Korponay-Szabo, I R
AU  - Korponay-Szabo IR
FAU - Mearin, M L
AU  - Mearin ML
FAU - Phillips, A
AU  - Phillips A
FAU - Shamir, R
AU  - Shamir R
FAU - Troncone, R
AU  - Troncone R
FAU - Giersiepen, K
AU  - Giersiepen K
FAU - Branski, D
AU  - Branski D
FAU - Catassi, C
AU  - Catassi C
FAU - Lelgeman, M
AU  - Lelgeman M
FAU - Maki, M
AU  - Maki M
FAU - Ribes-Koninckx, C
AU  - Ribes-Koninckx C
FAU - Ventura, A
AU  - Ventura A
FAU - Zimmer, K P
AU  - Zimmer KP
CN  - ESPGHAN Working Group on Coeliac Disease Diagnosis
CN  - ESPGHAN Gastroenterology Committee
CN  - European Society for Pediatric Gastroenterology, Hepatology, and Nutrition
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DQ8 antigen)
RN  - 0 (Immunoglobulin A)
RN  - EC 2.3.2.13 (Transglutaminases)
SB  - IM
EIN - J Pediatr Gastroenterol Nutr. 2012 Apr;54(4):572
CIN - J Pediatr Gastroenterol Nutr. 2012 Oct;55(4):e131. PMID: 22576672
CIN - J Pediatr Gastroenterol Nutr. 2012 Dec;55(6):733-5. PMID: 22744189
CIN - J Pediatr Gastroenterol Nutr. 2013 Oct;57(4):e24. PMID: 23820401
CIN - J Pediatr Gastroenterol Nutr. 2013 Oct;57(4):e24-5. PMID: 23820402
MH  - Adolescent
MH  - Celiac Disease/*diagnosis/immunology/pathology
MH  - Child
MH  - Duodenum/*pathology
MH  - HLA-DQ Antigens/*blood
MH  - Humans
MH  - Immunoglobulin A/*blood
MH  - Transglutaminases/*immunology
EDAT- 2011/12/27 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/12/27 06:00
PHST- 2011/12/27 06:00 [entrez]
PHST- 2011/12/27 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - 00005176-201201000-00028 [pii]
AID - 10.1097/MPG.0b013e31821a23d0 [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2012 Jan;54(1):136-60. doi: 
      10.1097/MPG.0b013e31821a23d0.