PMID- 22199264
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20220408
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 31
IP  - 12
DP  - 2011 Dec
TI  - L-type amino acid transporter 1 (LAT1) expression in malignant pleural 
      mesothelioma.
PG  - 4075-82
AB  - L-Type amino acid transporter 1 (LAT1) is known to be highly expressed in various 
      human neoplasms. However, little is known about how LAT1 is expressed in 
      malignant pleural mesothelioma (MPM). Twenty-one patients were included in this 
      study. Tumor sections were stained by immunohistochemistry for LAT1, glucose 
      transporter 1 (GLUT1), GLUT3, hypoxia inducible factor-1alpha (HIF-1alpha), hexokinase I, 
      vascular endothelial growth factor (VEGF), microvessel density (MVD) by 
      determination of CD34, epidermal growth factor receptor (EGFR), phosphatase and 
      tensin analog (PTEN), p-AKT, p-manmalian target of rapamycin (mTOR), p-S6K, p53 
      and BCL-2. LAT1 was overexpressed in approximately 50% of the patients with MPM. 
      LAT1 expression was closely correlated with CD98, hypoxic markers, the mTOR 
      pathway, Ki-67 and p53. The overexpression of LAT1 was closely associated with 
      poor outcome in patients with MPM. LAT1 is closely associated with tumor 
      development and progression in patients with MPM.
FAU - Kaira, Kyoichi
AU  - Kaira K
AD  - Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo 
      Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan. kkaira1970@yahoo.co.jp
FAU - Oriuchi, Noboru
AU  - Oriuchi N
FAU - Takahashi, Toshiaki
AU  - Takahashi T
FAU - Nakagawa, Kazuo
AU  - Nakagawa K
FAU - Ohde, Yasuhisa
AU  - Ohde Y
FAU - Okumura, Takehiro
AU  - Okumura T
FAU - Murakami, Haruyasu
AU  - Murakami H
FAU - Shukuya, Takehito
AU  - Shukuya T
FAU - Kenmotsu, Hirotsugu
AU  - Kenmotsu H
FAU - Naito, Tateaki
AU  - Naito T
FAU - Kanai, Yoshikatsu
AU  - Kanai Y
FAU - Endo, Masahiro
AU  - Endo M
FAU - Kondo, Haruhiko
AU  - Kondo H
FAU - Nakajima, Takashi
AU  - Nakajima T
FAU - Yamamoto, Nobuyuki
AU  - Yamamoto N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Large Neutral Amino Acid-Transporter 1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/metabolism
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Hypoxia
MH  - Immunohistochemistry/methods
MH  - Large Neutral Amino Acid-Transporter 1/*biosynthesis
MH  - Lung Neoplasms/*metabolism
MH  - Male
MH  - Mesothelioma/*metabolism
MH  - Middle Aged
MH  - Pleural Neoplasms/*metabolism
MH  - Treatment Outcome
EDAT- 2011/12/27 06:00
MHDA- 2012/02/23 06:00
CRDT- 2011/12/27 06:00
PHST- 2011/12/27 06:00 [entrez]
PHST- 2011/12/27 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - 31/12/4075 [pii]
PST - ppublish
SO  - Anticancer Res. 2011 Dec;31(12):4075-82.