PMID- 22199311
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20211203
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 31
IP  - 12
DP  - 2011 Dec
TI  - Immunohistochemical study of VEGF expression in oral squamous cell carcinomas: 
      correlation with the mTOR-HIF-1alpha pathway.
PG  - 4429-37
AB  - The aim of this study was to clarify the relationship between vascular 
      endothelial growth factor (VEGF) expression and clinicopathological factors in 
      oral squamous cell carcinoma (OSCC). We also examined the correlation between the 
      VEGF expression and the mammalian target of rapamycin (mTOR)-hypoxia inducible 
      factor-1alpha (HIF-1alpha) pathway. Formalin-fixed paraffin-embedded tissues from 120 
      OSCC cases and 10 samples of normal mucosa were stained immunohistochemically for 
      VEGF-A, VEGF-C, p-mTOR and HIF-1alpha proteins. VEGF-A and VEGF-C protein expression 
      was detected in 76 out of 120 (63%) and 81 of 120 (67.5%) OSCCs, respectively, 
      and their expression was significantly higher in primary OSCC than in normal oral 
      mucosa. VEGF-A expression was significantly associated with the tumor stage and 
      age. VEGF-C expression was significantly associated with the cancer cell 
      invasion. The cases with combined p-mTOR+/HIF-1alpha(+)/VEGF-A(+) expression had a 
      significantly higher tumor stage and invasion grade, and combined 
      p-mTOR+/HIF-1alpha(+)/VEGF-C(+) expression was significantly associated with tumor 
      stage, regional lymph node metastasis and invasion grade. In a survival analysis, 
      no obvious correlation was observed with any of the immunohistochemical results. 
      This study indicated that the mTOR-HIF-1alpha-VEGF pathway affects the progression of 
      OSCC, and inhibition of this pathway may be useful for the treatment of OSCC.
FAU - Naruse, Tomofumi
AU  - Naruse T
AD  - Department of Clinical Oral Oncology, Nagasaki University Graduate School of 
      Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki, Japan.
FAU - Kawasaki, Goro
AU  - Kawasaki G
FAU - Yanamoto, Souichi
AU  - Yanamoto S
FAU - Mizuno, Akio
AU  - Mizuno A
FAU - Umeda, Masahiro
AU  - Umeda M
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Vascular Endothelial Growth Factor C)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism
MH  - Case-Control Studies
MH  - Disease Progression
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*biosynthesis
MH  - Immunohistochemistry/*methods
MH  - Lymphatic Metastasis
MH  - Mouth Neoplasms/*metabolism
MH  - Neovascularization, Pathologic
MH  - TOR Serine-Threonine Kinases/*biosynthesis
MH  - Vascular Endothelial Growth Factor A/*biosynthesis
MH  - Vascular Endothelial Growth Factor C/*biosynthesis
EDAT- 2011/12/27 06:00
MHDA- 2012/02/23 06:00
CRDT- 2011/12/27 06:00
PHST- 2011/12/27 06:00 [entrez]
PHST- 2011/12/27 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - 31/12/4429 [pii]
PST - ppublish
SO  - Anticancer Res. 2011 Dec;31(12):4429-37.