PMID- 22199996
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1948-1756 (Electronic)
IS  - 1948-1756 (Linking)
VI  - 2
IP  - 4
DP  - 2011
TI  - Tumor necrosis factor-related genes and colon and rectal cancer.
PG  - 328-38
AB  - Tumor necrosis factor-alpha (TNF) is a promoter of inflammation. Genes in the TNF 
      pathway include tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), 
      TNF receptor-associated factor 2 (TRAF2), mitogen activated protein kinase 8 
      (MAPK8), 14 (MAPK14), and mitogen activated protein kinase kinase kinase 7 
      (MAP3K7), nuclear factor of activated-T-5 (NFAT5) cells and NFAT activated 
      protein with ITAM motif 1 ﹛NFAM1). Data from population-based studies of colon 
      cancer (cases=1,555; controls=1,956) and rectal cancer (cases=754; controls=959) 
      were used. We observed that MAP3K7 rs13208824 was associated with reduced colon 
      cancer risk (OR 0.83, 95% CI 0.71, 0.98 dominant model), TNF rs1800630 was 
      associated with an increased colon cancer risk (OR 1.19 95% CI 1.03, 1.38 for 
      CA/AAvsCC), and TNFRSF1A rs4149570 was associated with reduced risk (OR 0.79 95% 
      CI 0.64, 0.96 TTvsGG). For rectal cancer MAPK8 rs10508901 was associated with 
      increased risk (OR 1.45 95% CI 1.05, 1.99 AA vs CC/CA; NFAT5 (rs12447326 and 
      rs16959025) was associated with a 40% reduced risk for the recessive model. 
      Aspirin/NSAID interacted with MAP3K7 (colon cancer) and with MAPK14, NFAT5, and 
      TRAF2 (rectal cancer); smoking cigarettes interacted with NFAM1 and NFAT2 (colon 
      cancer) and MAPK8, NFAT5, and TNFRSF1A (rectal cancer); BMI interacted with NFAM1 
      and NFAT5 (colon cancer) and with MAPK8 and TNFRSF1A (rectal cancer). A genotype 
      summary score showed a threefold increased risk of dying with higher mutational 
      load. Although few independent associations were detected, aspirin/NSAID, 
      cigarette smoking, and BMI influenced genes in this pathway. These data suggest 
      pathways through which TNF-signaling operates.
FAU - Slattery, Martha L
AU  - Slattery ML
FAU - Lundgreen, Abbie
AU  - Lundgreen A
FAU - Bondurant, Kristina L
AU  - Bondurant KL
FAU - Wolff, Roger K
AU  - Wolff RK
LA  - eng
GR  - R01 CA048998/CA/NCI NIH HHS/United States
GR  - R01 CA061757/CA/NCI NIH HHS/United States
GR  - U01 CA048998/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20111020
PL  - United States
TA  - Int J Mol Epidemiol Genet
JT  - International journal of molecular epidemiology and genetics
JID - 101525762
PMC - PMC3243449
OTO - NOTNLM
OT  - Colon cancer
OT  - MAPK14
OT  - MAPK8
OT  - NFAM1
OT  - NFAT5
OT  - TNF
OT  - TNFRSF1A
OT  - TRAF2
OT  - rectal cancer
EDAT- 2011/12/27 06:00
MHDA- 2011/12/27 06:01
PMCR- 2011/10/20
CRDT- 2011/12/27 06:00
PHST- 2011/08/01 00:00 [received]
PHST- 2011/08/23 00:00 [accepted]
PHST- 2011/12/27 06:00 [entrez]
PHST- 2011/12/27 06:00 [pubmed]
PHST- 2011/12/27 06:01 [medline]
PHST- 2011/10/20 00:00 [pmc-release]
PST - ppublish
SO  - Int J Mol Epidemiol Genet. 2011;2(4):328-38. Epub 2011 Oct 20.