PMID- 22200000
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1948-1756 (Electronic)
IS  - 1948-1756 (Linking)
VI  - 2
IP  - 4
DP  - 2011
TI  - Biomarkers of inflammation and hemostasis associated with left ventricular mass: 
      The Multiethnic Study of Atherosclerosis (MESA).
PG  - 391-400
AB  - PURPOSE: Biomarkers of inflammation and hemostasis have been associated with left 
      ventricular (LV) mass. We studied relationships of C-reactive protein (CRP), 
      interleukin-6 (IL6), D-dimer, soluble intercellular adhesion molecule-1 
      (sICAM-1), plasminogen activator inhibitor 1 (PAI-1), soluble thrombomodulin 
      (sTM), soluble tumor necrosis factor type 1 receptor (sTNFR1), von Willebrand 
      factor (vWF), soluble E-selectin (sE-selectin), factor VIII, fibrinogen, matrix 
      metalloproteinase 3 (MMP3), and matrix metalloproteinase 9 (MMP9) with LV mass in 
      an asymptomatic population. Multi-Ethnic Study of Atherosclerosis participants 
      underwent magnetic resonance imaging to characterize LV mass; biomarkers were 
      measured using standardized protocols (N = 763 to 4979). Adjusted models were 
      used to associate each biomarker with LV mass while correcting for potential 
      confounding. FINDINGS: LV mass was associated with many biomarkers after 
      adjustment for demographic characteristics and traditional cardiovascular risk 
      factors. Although the demographic and risk factor adjustments attenuated the 
      association of CRP and IL6 with LV mass, further adjustment for weight changed 
      regression coefficients from positive to negative for CRP and IL6 for LV mass. 
      sTM, Factor VIII, and vWF were directly associated with LV mass in fully-adjusted 
      models. For sTNFR1, sICAM-1, D-dimer, fibrinogen, and PAI-1, adjustment for risk 
      factors and weight rendered associations with LV mass nonsignificant. 
      CONCLUSIONS: In this large cohort free of clinical cardiovascular disease, 
      several hemostasis and inflammation markers were associated with LV mass. The 
      unusual finding of a negative relationship of CRP and IL6 with LV mass only after 
      adjustment for weight suggests that the effects of inflammation on LV mass are 
      strongly influenced by obesity.
FAU - Arnett, Donna K
AU  - Arnett DK
FAU - McClelland, Robyn L
AU  - McClelland RL
FAU - Bank, Alan
AU  - Bank A
FAU - Bluemke, David A
AU  - Bluemke DA
FAU - Cushman, Mary
AU  - Cushman M
FAU - Szalai, Alexander J
AU  - Szalai AJ
FAU - Jain, Nishank
AU  - Jain N
FAU - Gomes, Antoinette S
AU  - Gomes AS
FAU - Heckbert, Susan R
AU  - Heckbert SR
FAU - Hundley, W Gregory
AU  - Hundley WG
FAU - Lima, Joao A
AU  - Lima JA
LA  - eng
GR  - N01HC95159/HL/NHLBI NIH HHS/United States
GR  - N01HC95166/HL/NHLBI NIH HHS/United States
GR  - N01HC95168/HL/NHLBI NIH HHS/United States
GR  - UL1 RR024156/RR/NCRR NIH HHS/United States
PT  - Journal Article
DEP - 20111128
PL  - United States
TA  - Int J Mol Epidemiol Genet
JT  - International journal of molecular epidemiology and genetics
JID - 101525762
PMC - PMC3243453
OTO - NOTNLM
OT  - Left ventricle
OT  - biomarker
OT  - hemostasis
OT  - inflammation
EDAT- 2011/12/27 06:00
MHDA- 2011/12/27 06:01
PMCR- 2011/11/28
CRDT- 2011/12/27 06:00
PHST- 2011/11/14 00:00 [received]
PHST- 2011/11/20 00:00 [accepted]
PHST- 2011/12/27 06:00 [entrez]
PHST- 2011/12/27 06:00 [pubmed]
PHST- 2011/12/27 06:01 [medline]
PHST- 2011/11/28 00:00 [pmc-release]
PST - ppublish
SO  - Int J Mol Epidemiol Genet. 2011;2(4):391-400. Epub 2011 Nov 28.