PMID- 22201277
OWN - NLM
STAT- MEDLINE
DCOM- 20120604
LR  - 20120220
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 132
IP  - 3
DP  - 2012 Mar
TI  - Biological and clinical significance of p75NTR expression in laryngeal squamous 
      epithelia and laryngocarcinoma.
PG  - 314-24
LID - 10.3109/00016489.2011.639086 [doi]
AB  - CONCLUSION: The apparent features of p75 neurotrophin receptor (p75(NTR)) 
      expression indicated that p75(NTR) would serve as a potential stem cell marker 
      for normal human laryngeal squamous epithelia. In human laryngeal squamous cell 
      carcinoma (LSCC) p75(NTR) is differentially expressed. The abnormal expression 
      and distribution of p75(NTR) may indicate malignant transformation. OBJECTIVE: To 
      investigate the expression of p75(NTR) and its possible roles in normal laryngeal 
      squamous epithelia and LSCC. METHODS: We used immunohistochemistry methods to 
      examine normal laryngeal epithelia, para-cancer mucosa with dysplasia, laryngeal 
      papilloma, and LSCC specimens for the expression of p75(NTR), nerve growth factor 
      (NGF), -tyrosine kinase receptor (TrkA), p63, and Ki67. Immunocytochemistry and 
      flow cytometry were used to examine the expression of p75(NTR) in Hep-2 cells. 
      RESULTS: The expression of p75(NTR) was only located in basal cells of normal 
      laryngeal epithelia, consistent with the staining features of epithelial stem 
      cells as evidenced by parallel staining of p63, a putative keratinocyte stem cell 
      marker. p75(NTR) is differentially expressed in LSCC, although no significant 
      relationship was found with many clinicopathologic factors, this expression and 
      distribution may correlate to malignant transformation and tumor proliferation. 
      Co-expression of p75(NTR) and CD133 was confirmed, showing the association of 
      p75(NTR)-positive cells with cancer stem cells in Hep-2 cells.
FAU - Li, Xiaoming
AU  - Li X
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Center for 
      Otorhinolaryngological Diseases, Shijiazhuang, China. xmlmo@126.com
FAU - Shen, Yupeng
AU  - Shen Y
FAU - Di, Bin
AU  - Di B
FAU - Li, Jun
AU  - Li J
FAU - Geng, Jiangqiao
AU  - Geng J
FAU - Lu, Xiuying
AU  - Lu X
FAU - He, Zhanguo
AU  - He Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111227
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (Receptor, Nerve Growth Factor)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Cells, Cultured
MH  - Flow Cytometry
MH  - Hep G2 Cells
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Mucosa/*metabolism/pathology
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Neoplastic Stem Cells/metabolism
MH  - Papilloma/metabolism
MH  - Precancerous Conditions/*metabolism/pathology
MH  - Protein-Tyrosine Kinases/metabolism
MH  - Receptor, Nerve Growth Factor/*metabolism
EDAT- 2011/12/29 06:00
MHDA- 2012/06/05 06:00
CRDT- 2011/12/29 06:00
PHST- 2011/12/29 06:00 [entrez]
PHST- 2011/12/29 06:00 [pubmed]
PHST- 2012/06/05 06:00 [medline]
AID - 10.3109/00016489.2011.639086 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2012 Mar;132(3):314-24. doi: 10.3109/00016489.2011.639086. Epub 
      2011 Dec 27.