PMID- 22201588
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20190918
IS  - 1873-4316 (Electronic)
IS  - 1389-2010 (Linking)
VI  - 13
IP  - 7
DP  - 2012 Jun
TI  - Nanocarriers for the simultaneous co-delivery of therapeutic genes and anticancer 
      drugs.
PG  - 1317-31
AB  - Due to the molecular complexity of cancer, combination therapy is becoming 
      increasingly important for better long-term prognosis with fewer side effects. To 
      further increase the therapeutic effects, advanced drug delivery systems (DDSs), 
      capable of simultaneously delivering multiple drugs to the site of action with 
      specific time-programmed release profiles, are important requirements. 
      Nanocarriers for the simultaneous co-delivery of multiple chemical drugs in 
      combination therapy have been extensively reviewed. Here we focus on the 
      nanotechnology enabled DDSs for the simultaneous co-delivery of therapeutic genes 
      and chemical drugs for cancer treatment. The opportunities for this combination 
      strategy and their challenges will be discussed.
FAU - Choudhury, Nazia N
AU  - Choudhury NN
AD  - Department of Chemistry, Rutgers, State University of New Jersey, Newark, USA.
FAU - He, Huixin
AU  - He H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - Netherlands
TA  - Curr Pharm Biotechnol
JT  - Current pharmaceutical biotechnology
JID - 100960530
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*administration & dosage
MH  - Combined Modality Therapy/methods
MH  - Drug Carriers/*administration & dosage
MH  - Drug Delivery Systems/*methods
MH  - Genetic Therapy/*methods
MH  - Genetic Vectors/*administration & dosage
MH  - Humans
MH  - Nanoparticles/*administration & dosage
MH  - Neoplasms/drug therapy/genetics/*therapy
EDAT- 2011/12/29 06:00
MHDA- 2013/01/17 06:00
CRDT- 2011/12/29 06:00
PHST- 2010/09/30 00:00 [received]
PHST- 2010/12/19 00:00 [accepted]
PHST- 2011/12/29 06:00 [entrez]
PHST- 2011/12/29 06:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
AID - BSP/CPB/E-Pub/0000203-13-9 [pii]
AID - 10.2174/138920112800624418 [doi]
PST - ppublish
SO  - Curr Pharm Biotechnol. 2012 Jun;13(7):1317-31. doi: 10.2174/138920112800624418.