PMID- 22201766
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20220224
IS  - 2768-6698 (Electronic)
IS  - 2768-6698 (Linking)
VI  - 17
IP  - 2
DP  - 2012 Jan 1
TI  - Enhancing graft-versus-leukemia after transplant: the rise of anti-cancer 
      vaccines.
PG  - 635-55
AB  - Allogeneic hematopoietic stem cell transplantation (HSCT) remains the only truly 
      effective curative treatment for refractory hematological malignancies. 
      Unfortunately, relapse and transplant rejection continue to be of major concern. 
      In order to enhance the effectiveness of the HSCT, various strategies have been 
      explored to amplify the graft versus leukemia (GvL) effect. Cancer vaccines have 
      emerged in recent years as a promising strategy for the immunotherapeutic 
      treatment of cancer. Evidence shows that they are most likely to have the 
      greatest effect in the setting of minimal residual disease and as adjuvant 
      agents. With this in mind, researchers have begun to explore the use of cancer 
      vaccines in conjunction with HSCT, with exciting results. There has also been 
      recent work examining the effect of novel adjuvants or blockers of negative 
      immune regulation to augment the effect of cancer vaccines in both the transplant 
      and non-transplant settings. The addition of these agents may prove.
FAU - Brusic, Ana
AU  - Brusic A
AD  - Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
FAU - Wu, Catherine J
AU  - Wu CJ
LA  - eng
GR  - 5R21CA115043-2/CA/NCI NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120101
PL  - Singapore
TA  - Front Biosci (Landmark Ed)
JT  - Frontiers in bioscience (Landmark edition)
JID - 101612996
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Adjuvants, Immunologic/administration & dosage
MH  - Antigens, Neoplasm
MH  - B-Lymphocytes/immunology
MH  - Cancer Vaccines/administration & dosage/*therapeutic use
MH  - Graft vs Leukemia Effect/*immunology
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Humans
MH  - Leukemia/immunology/therapy
MH  - T-Lymphocytes/immunology
MH  - Tissue Donors
MH  - Transplantation, Homologous
EDAT- 2011/12/29 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/12/29 06:00
PHST- 2011/12/29 06:00 [entrez]
PHST- 2011/12/29 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - 3949 [pii]
AID - 10.2741/3949 [doi]
PST - epublish
SO  - Front Biosci (Landmark Ed). 2012 Jan 1;17(2):635-55. doi: 10.2741/3949.