PMID- 22201912
OWN - NLM
STAT- MEDLINE
DCOM- 20120514
LR  - 20220318
IS  - 1945-0508 (Electronic)
IS  - 1945-0494 (Linking)
VI  - 4
IP  - 2
DP  - 2012 Jan 1
TI  - Role of sirtuins, calorie restriction and physical activity in aging.
PG  - 768-78
AB  - Recently it has been discovered that Sirtuins represent pivotal regulators of 
      lifespan. Caloric restriction (CR) enhances longevity from yeast to mammals. 
      Whereas the relationship between Sirt-1 and CR is clear, the molecular mechanisms 
      by which Sir2 increases longevity are still unknown. In mammals, CR induces 
      physiological and behavioral changes, and many studies have shown that CR 
      decreases production of reactive oxygen species production thus minimizing 
      oxidative damage, leading to the hypothesis that CR by reducing oxidative stress 
      extends the lifespan by counteraction of aging. In fact, the pathophysiology of 
      aging and age-related diseases involves oxidative stress as an early stage in its 
      development. Recently we found that in aged rats the SIRT1 activity was decreased 
      in heart and adipose tissue, showing as aging is characterized in vivo by a 
      reduced efficiency of this key-regulator of longevity. Whereas several studies 
      have reported that increased physical activity can improve mean life span 
      presumably by reducing mortality risk from many age-related diseases, exercise 
      and longevity studies have failed to document an exercise effect on maximum life 
      span. However, in aged rats a moderate prolonged exercise training is able to 
      induce increase in SIRT1 activity, suggesting that this tool could counteract 
      age-related dysfunctions.
FAU - Corbi, Graziamaria
AU  - Corbi G
AD  - Department of Health Sciences, Faculty of Medicine and Surgery, University of 
      Molise, via Giovanni Paolo II -Localita Tappino, 86100 Campobasso, Italy. 
      graziamaria.corbi@unimol.it
FAU - Conti, Valeria
AU  - Conti V
FAU - Scapagnini, Giovanni
AU  - Scapagnini G
FAU - Filippelli, Amelia
AU  - Filippelli A
FAU - Ferrara, Nicola
AU  - Ferrara N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120101
PL  - Singapore
TA  - Front Biosci (Elite Ed)
JT  - Frontiers in bioscience (Elite edition)
JID - 101485240
RN  - EC 3.5.1.- (Sirtuins)
SB  - IM
MH  - Aging/*physiology
MH  - *Caloric Restriction
MH  - Humans
MH  - Sirtuins/*physiology
MH  - *Stress, Physiological
EDAT- 2011/12/29 06:00
MHDA- 2012/05/15 06:00
CRDT- 2011/12/29 06:00
PHST- 2011/12/29 06:00 [entrez]
PHST- 2011/12/29 06:00 [pubmed]
PHST- 2012/05/15 06:00 [medline]
AID - 417 [pii]
AID - 10.2741/417 [doi]
PST - epublish
SO  - Front Biosci (Elite Ed). 2012 Jan 1;4(2):768-78. doi: 10.2741/417.