PMID- 22202032
OWN - NLM
STAT- MEDLINE
DCOM- 20120514
LR  - 20220223
IS  - 1945-0508 (Electronic)
IS  - 1945-0494 (Print)
IS  - 1945-0494 (Linking)
VI  - 4
IP  - 6
DP  - 2012 Jan 1
TI  - L1 expression and regulation in humans and rodents.
PG  - 2203-25
AB  - Long interspersed elements type 1 (LINE-1s, or L1s) have impacted mammalian 
      genomes at multiple levels. L1 transcription is mainly controlled by its 5' 
      untranslated region (5'UTR), which differs significantly among active human and 
      rodent L1 families. In this review, L1 expression and its regulation are examined 
      in the context of human and rodent development. First, endogenous L1 expression 
      patterns in three different species-human, rat, and mouse-are compared and 
      contrasted. A detailed account of relevant experimental evidence is presented 
      according to the source material, such as cell lines, tumors, and normal somatic 
      and germline tissues from different developmental stages. Second, factors 
      involved in the regulation of L1 expression at both transcriptional and 
      posttranscriptional levels are discussed. These include transcription factors, 
      DNA methylation, PIWI-interacting RNAs (piRNAs), RNA interference (RNAi), and 
      posttranscriptional host factors. Similarities and differences between human and 
      rodent L1s are highlighted. Third, recent findings from transgenic mouse models 
      of L1 are summarized and contrasted with those from endogenous L1 studies. 
      Finally, the challenges and opportunities for L1 mouse models are discussed.
FAU - Rosser, James M
AU  - Rosser JM
AD  - School of Molecular Biosciences and Center for Reproductive Biology, Washington 
      State University, Pullman, WA 99164, USA.
FAU - An, Wenfeng
AU  - An W
LA  - eng
GR  - T32 GM008336/GM/NIGMS NIH HHS/United States
GR  - 5T32GM008336-22/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120101
PL  - Singapore
TA  - Front Biosci (Elite Ed)
JT  - Frontiers in bioscience (Elite edition)
JID - 101485240
SB  - IM
MH  - Animals
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Long Interspersed Nucleotide Elements/*genetics
MH  - Mice
MH  - Mice, Transgenic
PMC - PMC4457320
MID - NIHMS692886
EDAT- 2011/12/29 06:00
MHDA- 2012/05/15 06:00
PMCR- 2015/06/05
CRDT- 2011/12/29 06:00
PHST- 2011/12/29 06:00 [entrez]
PHST- 2011/12/29 06:00 [pubmed]
PHST- 2012/05/15 06:00 [medline]
PHST- 2015/06/05 00:00 [pmc-release]
AID - 537 [pii]
AID - 10.2741/537 [doi]
PST - epublish
SO  - Front Biosci (Elite Ed). 2012 Jan 1;4(6):2203-25. doi: 10.2741/537.