PMID- 22202101
OWN - NLM
STAT- MEDLINE
DCOM- 20130805
LR  - 20240504
IS  - 1945-0524 (Electronic)
IS  - 1945-0516 (Print)
IS  - 1945-0516 (Linking)
VI  - 4
IP  - 3
DP  - 2012 Jan 1
TI  - The role of mTOR signaling in Alzheimer disease.
PG  - 941-52
AB  - The buildup of Abeta and tau is believed to directly cause or contribute to the 
      progressive cognitive deficits characteristic of Alzheimer disease. However, the 
      molecular pathways linking Abeta and tau accumulation to learning and memory 
      deficits remain elusive. There is growing evidence that soluble forms of Abeta 
      and tau can obstruct learning and memory by interfering with several signaling 
      cascades. In this review, I will present data showing that the mammalian target 
      of rapamycin (mTOR) may play a role in Abeta and tau induced neurodegeneration.
FAU - Oddo, Salvatore
AU  - Oddo S
AD  - Department of Physiology, University of Texas Health Science Center at San 
      Antonio, San Antonio, TX 78229-3900, USA. oddo@uthscsa.edu
LA  - eng
GR  - K99 AG029729/AG/NIA NIH HHS/United States
GR  - RC2AG036613/AG/NIA NIH HHS/United States
GR  - RC2 AG036613/AG/NIA NIH HHS/United States
GR  - K99/R00 AG29729-4/AG/NIA NIH HHS/United States
GR  - R00 AG029729/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20120101
PL  - Singapore
TA  - Front Biosci (Schol Ed)
JT  - Frontiers in bioscience (Scholar edition)
JID - 101485241
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Alzheimer Disease/*metabolism
MH  - Animals
MH  - Humans
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC4111148
MID - NIHMS606146
EDAT- 2011/12/29 06:00
MHDA- 2013/08/06 06:00
PMCR- 2014/07/25
CRDT- 2011/12/29 06:00
PHST- 2011/12/29 06:00 [entrez]
PHST- 2011/12/29 06:00 [pubmed]
PHST- 2013/08/06 06:00 [medline]
PHST- 2014/07/25 00:00 [pmc-release]
AID - 310 [pii]
AID - 10.2741/s310 [doi]
PST - epublish
SO  - Front Biosci (Schol Ed). 2012 Jan 1;4(3):941-52. doi: 10.2741/s310.