PMID- 22204478
OWN - NLM
STAT- MEDLINE
DCOM- 20120723
LR  - 20120301
IS  - 1366-5804 (Electronic)
IS  - 1354-750X (Linking)
VI  - 17
IP  - 2
DP  - 2012 Mar
TI  - Association of HLA-DRB1*14 with rheumatic heart disease patients from Chandigarh, 
      North India.
PG  - 160-5
LID - 10.3109/1354750X.2011.645556 [doi]
AB  - CONTEXT: Acute rheumatic fever (ARF)/rheumatic heart disease (RHD) is a major 
      cause of morbidity and mortality in India, yet, few studies are available on 
      susceptibility markers. OBJECTIVE: To associate human leukocyte antigen (HLA) 
      class II alleles with north Indian RHD patients as genetic susceptibility 
      markers. MATERIALS AND METHODS: HLA alleles were analysed using sequence specific 
      primer-polymerase chain reaction and nucleotide sequencing, while HLA-B27 
      expression by flowcytometry. RESULTS: Few HLA-DQB1/DRB1 alleles were associated 
      with RHD and HLA-DRB1*14 gene polymorphism revealed two single nucleotide 
      polymorphisms (SNPs) in patients. Bioinformatic predictions showed influence of 
      SNPs on protein function. HLA-B27 was positive in 42.85% ARF patients. 
      CONCLUSION: The study showed association of different HLA class II alleles with 
      RHD in North Indian population.
FAU - Toor, Devinder
AU  - Toor D
AD  - Department of Experimental Medicine and Biotechnology, Chandigarh, India.
FAU - Leal, Komal
AU  - Leal K
FAU - Kumar, Rajesh
AU  - Kumar R
FAU - Sharma, Yash Paul
AU  - Sharma YP
FAU - Chakraborti, Anuradha
AU  - Chakraborti A
LA  - eng
PT  - Journal Article
DEP - 20111229
PL  - England
TA  - Biomarkers
JT  - Biomarkers : biochemical indicators of exposure, response, and susceptibility to 
      chemicals
JID - 9606000
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Child
MH  - DNA Mutational Analysis
MH  - Female
MH  - Flow Cytometry
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-B27 Antigen/*genetics
MH  - HLA-DQ beta-Chains/*genetics
MH  - Haplotypes
MH  - Humans
MH  - India
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Rheumatic Heart Disease/*genetics
EDAT- 2011/12/30 06:00
MHDA- 2012/07/24 06:00
CRDT- 2011/12/30 06:00
PHST- 2011/12/30 06:00 [entrez]
PHST- 2011/12/30 06:00 [pubmed]
PHST- 2012/07/24 06:00 [medline]
AID - 10.3109/1354750X.2011.645556 [doi]
PST - ppublish
SO  - Biomarkers. 2012 Mar;17(2):160-5. doi: 10.3109/1354750X.2011.645556. Epub 2011 
      Dec 29.