PMID- 22204768
OWN - NLM
STAT- MEDLINE
DCOM- 20120906
LR  - 20111229
IS  - 1944-7930 (Electronic)
IS  - 1539-6509 (Linking)
VI  - 12
IP  - 67
DP  - 2011 Dec
TI  - IL-13 and its genetic variants: effect on current asthma treatments.
PG  - 513-23
AB  - Airway hyperresponsiveness is an essential part of the definition of asthma 
      associated temporally with exposure to allergens, certain respiratory viruses, 
      pollutants such as ozone, and certain organic chemicals. Interleukin-13 (IL-13) 
      is implicated as a central regulator in immunoglobulin E (IgE) synthesis, mucus 
      hypersecretion, airway hyperresponsiveness, and fibrosis. The importance of IL-13 
      in allergic disorders in humans is supported by consistent associations between 
      tissue IL-13 levels and genetic variants in the IL-13 gene and asthma and related 
      traits. Single-nucleotide polymorphisms in IL-13 are associated with allergic 
      phenotypes in several ethnically diverse populations. Glucocorticoids are 
      anti-inflammatory medications often used as maintenance therapy in acute and 
      chronic asthma; however, some patients with severe asthma are steroid resistant. 
      IL-13 remains elevated in glucocorticoid insensitive asthma but not in 
      glucocorticoid sensitive asthma. Thus targeting IL-13 and its associated 
      receptors may be a therapeutic approach to the treatment of asthma and/or 
      allergy. This review focuses on the role of IL-13 on airway hyperresponsiveness 
      and corticosteroids resistant asthma both preclinically and clinically.
CI  - (c) Discovery Medicine
FAU - Townley, Robert G
AU  - Townley RG
AD  - Division of Asthma, Allergy, and Immunology, Department of Medicine, Creighton 
      University School of Medicine, 601N, 30th St., Omaha, Nebraska 68131, USA. 
      roberttownley@creighton.edu
FAU - Sapkota, Muna
AU  - Sapkota M
FAU - Sapkota, Kiran
AU  - Sapkota K
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Discov Med
JT  - Discovery medicine
JID - 101250006
RN  - 0 (Interleukin-13)
RN  - 0 (Receptors, Interleukin-13)
SB  - IM
MH  - Asthma/complications/*drug therapy/*genetics/physiopathology
MH  - Bronchial Hyperreactivity/complications/physiopathology
MH  - Humans
MH  - Interleukin-13/*genetics
MH  - Mutation/*genetics
MH  - Receptors, Interleukin-13/metabolism
MH  - Signal Transduction
EDAT- 2011/12/30 06:00
MHDA- 2012/09/07 06:00
CRDT- 2011/12/30 06:00
PHST- 2011/12/30 06:00 [entrez]
PHST- 2011/12/30 06:00 [pubmed]
PHST- 2012/09/07 06:00 [medline]
PST - ppublish
SO  - Discov Med. 2011 Dec;12(67):513-23.