PMID- 22204860
OWN - NLM
STAT- MEDLINE
DCOM- 20120803
LR  - 20131121
IS  - 1578-8989 (Electronic)
IS  - 0025-7753 (Linking)
VI  - 138
IP  - 11
DP  - 2012 Apr 28
TI  - The rate of primary hypothyroidism in diabetic patients is greater than in the 
      non-diabetic population. An observational study.
PG  - 475-7
LID - 10.1016/j.medcli.2011.08.009 [doi]
AB  - BACKGROUND AND OBJECTIVE: The aim of our study was to identify the rate of 
      diabetic patients treated for hypothyroidism and compare them with a group 
      without type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS: We reviewed the 
      computerized clinical records of 5161 patients. We identified diabetic patients 
      treated with l-thyroxine. We compared the prevalence of PH with those patients 
      under treatment with levothyroxine without T2DM. We excluded patients with a 
      thyroid neoplasia, thyroid surgery, panhypopituitarism, or surgical complications 
      of multinodular goiter or a thyroid nodule. Subclinical hypothyroidism was not 
      considered. RESULTS: We included 1848 adult patients with T2DM in the study 
      group, 58% women and 42% men. For the control group, we included 3313 
      non-diabetic patients, 55% women and 45% men. The mean age in the study group was 
      52+/-7 years, and 47+/-4 years in the control group (p<.001). The rate of 
      hypothyroidism in the study group was 5.7%, and in the control group 1.8% (odds 
      ratio of 3.45; 95% confidence interval 2.51-4.79) (p<.001). CONCLUSION: A strong 
      association between T2DM and hypothyroidism was found. We recommend a thyroid 
      profile in all patients with T2DM, similar to the recommendation in type 1 
      diabetes mellitus.
CI  - Copyright (c) 2011 Elsevier Espana, S.L. All rights reserved.
FAU - Tamez-Perez, Hector-Eloy
AU  - Tamez-Perez HE
AD  - Subdireccion de Investigacion, Facultad de Medicina U.A.N.L., Monterrey, NL, 
      Mexico. hectoreloytamez@aol.com
FAU - Martinez, Esteban
AU  - Martinez E
FAU - Quintanilla-Flores, Dania L
AU  - Quintanilla-Flores DL
FAU - Tamez-Pena, Alejandra L
AU  - Tamez-Pena AL
FAU - Gutierrez-Hermosillo, Hugo
AU  - Gutierrez-Hermosillo H
FAU - Diaz de Leon-Gonzalez, Enrique
AU  - Diaz de Leon-Gonzalez E
LA  - eng
PT  - Journal Article
DEP - 20111226
PL  - Spain
TA  - Med Clin (Barc)
JT  - Medicina clinica
JID - 0376377
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Humans
MH  - Hypothyroidism/*complications/drug therapy/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Retrospective Studies
MH  - Thyroxine/therapeutic use
EDAT- 2011/12/30 06:00
MHDA- 2012/08/04 06:00
CRDT- 2011/12/30 06:00
PHST- 2011/06/27 00:00 [received]
PHST- 2011/08/22 00:00 [revised]
PHST- 2011/08/27 00:00 [accepted]
PHST- 2011/12/30 06:00 [entrez]
PHST- 2011/12/30 06:00 [pubmed]
PHST- 2012/08/04 06:00 [medline]
AID - S0025-7753(11)01133-X [pii]
AID - 10.1016/j.medcli.2011.08.009 [doi]
PST - ppublish
SO  - Med Clin (Barc). 2012 Apr 28;138(11):475-7. doi: 10.1016/j.medcli.2011.08.009. 
      Epub 2011 Dec 26.