PMID- 22205264
OWN - NLM
STAT- MEDLINE
DCOM- 20120621
LR  - 20151119
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 158
IP  - 1
DP  - 2012
TI  - Temporal changes in total serum immunoglobulin E levels in East German children 
      and the effect of potential predictors.
PG  - 27-34
LID - 10.1159/000329855 [doi]
AB  - BACKGROUND: Elevated total serum immunoglobulin E (IgE) levels are a prominent 
      feature of allergic and parasitic diseases. An epidemiologic study was conducted 
      in East German children to describe trends in the development of total serum IgE 
      levels and analyze the impact of potential determinants. METHODS: The study 
      consisted of three cross-sectional surveys in 1992-1993, 1995-1996 and 1998-1999 
      and was conducted in three areas of the former German Democratic Republic. In 
      total, 8,051 questionnaires were completed by the parents of children aged 5-14 
      years, supplying information on allergic symptoms and potential risk factors. A 
      total of 5,918 measurements of total serum IgE and specific IgE to 5 common 
      aeroallergens were available from 4,353 schoolchildren. Generalized estimating 
      equations were applied to data from all children and stratified for atopic and 
      nonatopic children to identify trends and estimate the effect of potential 
      determinants on total IgE. RESULTS: Total serum IgE levels decreased 
      significantly with a linear trend in East German schoolchildren between 1992 and 
      1999, the effect being stronger in nonatopic children. The following factors were 
      associated with lower total serum IgE levels: female gender, living in a 
      household with fewer than 4 people, no history of helminth infestation, younger 
      age group (5-7 years), no parental allergy and high socioeconomic status. No 
      association was seen for 'smoking at home' and close contact to pets. CONCLUSION: 
      Total serum IgE declined parallel to helminth infestation; however, the latter 
      explained the decrease only in part. Furthermore, total IgE developed in an 
      opposite direction to specific IgE, indicating that it has determinants other 
      than allergic sensitization.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Flohrs, Katrin
AU  - Flohrs K
AD  - Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 
      Institute of Epidemiology, Neuherberg, Germany.
FAU - Bruske, Irene
AU  - Bruske I
FAU - Thiering, Elisabeth
AU  - Thiering E
FAU - Rzehak, Peter
AU  - Rzehak P
FAU - Wichmann, H-Erich
AU  - Wichmann HE
FAU - Heinrich, Joachim
AU  - Heinrich J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111228
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Allergens)
RN  - 0 (Antigens, Helminth)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/immunology
MH  - Antigens, Helminth/immunology
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Female
MH  - Germany/epidemiology
MH  - Humans
MH  - Hypersensitivity/blood/immunology
MH  - Immunoglobulin E/*blood/immunology
MH  - Male
MH  - Risk Factors
MH  - Sex Factors
MH  - Surveys and Questionnaires
EDAT- 2011/12/30 06:00
MHDA- 2012/06/22 06:00
CRDT- 2011/12/30 06:00
PHST- 2011/03/02 00:00 [received]
PHST- 2011/05/27 00:00 [accepted]
PHST- 2011/12/30 06:00 [entrez]
PHST- 2011/12/30 06:00 [pubmed]
PHST- 2012/06/22 06:00 [medline]
AID - 000329855 [pii]
AID - 10.1159/000329855 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2012;158(1):27-34. doi: 10.1159/000329855. Epub 2011 
      Dec 28.