PMID- 22205445
OWN - NLM
STAT- MEDLINE
DCOM- 20120907
LR  - 20211021
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 22
IP  - 6
DP  - 2012 Jun
TI  - The role of breast MR imaging in pre-operative determination of invasive disease 
      for ductal carcinoma in situ diagnosed by needle biopsy.
PG  - 1255-64
LID - 10.1007/s00330-011-2357-2 [doi]
AB  - OBJECTIVES: To evaluate whether magnetic resonance (MR) imaging features can 
      predict the presence of occult invasion in cases of biopsy-proven pure ductal 
      carcinoma in situ (DCIS). METHODS: We retrospectively reviewed 92 biopsy-proven 
      pure DCIS in 92 women who underwent MR imaging. The following MR imaging findings 
      were compared between confirmed DCIS and invasive breast cancer (IBC): lesion 
      size, type, morphological and kinetic assessments by ACR BI-RADS MRI, and 
      findings of fat-suppressed T2-weighted (FS-T2W) imaging. RESULTS: Sixty-eight of 
      92 (74%) were non-mass-like enhancements (NMLE) and 24 were mass lesions on MR 
      imaging. Twenty-one of 68 (31%) NMLE and 13 of 24 (54%) mass lesions were 
      confirmed as IBC. In NMLE lesions, large lesions (P = 0.007) and higher signal 
      intensities (SI) on FS-T2W images (P = 0.032) were significantly associated with 
      IBC. Lesion size remained a significant independent predictor of invasion in 
      multivariate analysis (P = 0.032), and combined with FS-T2W SIs showed slightly 
      higher observer performances (area under the curve, AUC, 0.71) than lesion size 
      alone (AUC 0.68). There were no useful findings that enabled the differentiation 
      of mass-type lesions. CONCLUSIONS: Breast MR imaging is potentially useful to 
      predict the presence of occult invasion in biopsy-proven DCIS with NMLE. KEY 
      POINTS: MR mammography permits more precise lesion assessment including ductal 
      carcinoma in situ A correct diagnosis of occult invasion before treatment is 
      important for clinicians This study showed the potential of MR mammography to 
      diagnose occult invasion Treatment and/or aggressive biopsy can be given with 
      greater confidence MR mammography can lead to more appropriate management of 
      patients.
FAU - Goto, Mariko
AU  - Goto M
AD  - Departments of Radiology, Graduate School of Medical Science, Kyoto Prefectural 
      University of Medicine, 465 Kajiicho, Kawaramachi Hirokoji, Kamigyoku, 602-8566 
      Kyoto, Japan. gomari@koto.kpu-m.ac.jp
FAU - Yuen, Sachiko
AU  - Yuen S
FAU - Akazawa, Kentaro
AU  - Akazawa K
FAU - Nishida, Kaori
AU  - Nishida K
FAU - Konishi, Eiichi
AU  - Konishi E
FAU - Kajihara, Mariko
AU  - Kajihara M
FAU - Shinkura, Nobuhiko
AU  - Shinkura N
FAU - Yamada, Kei
AU  - Yamada K
LA  - eng
PT  - Journal Article
DEP - 20111230
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biopsy, Needle/*statistics & numerical data
MH  - Breast Neoplasms/*epidemiology/*pathology/surgery
MH  - Carcinoma, Ductal/*epidemiology/*pathology/surgery
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Japan/epidemiology
MH  - Magnetic Resonance Imaging/*statistics & numerical data
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Preoperative Care/statistics & numerical data
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sensitivity and Specificity
EDAT- 2011/12/30 06:00
MHDA- 2012/09/08 06:00
CRDT- 2011/12/30 06:00
PHST- 2011/07/18 00:00 [received]
PHST- 2011/11/14 00:00 [accepted]
PHST- 2011/10/25 00:00 [revised]
PHST- 2011/12/30 06:00 [entrez]
PHST- 2011/12/30 06:00 [pubmed]
PHST- 2012/09/08 06:00 [medline]
AID - 10.1007/s00330-011-2357-2 [doi]
PST - ppublish
SO  - Eur Radiol. 2012 Jun;22(6):1255-64. doi: 10.1007/s00330-011-2357-2. Epub 2011 Dec 
      30.