PMID- 22205508
OWN - NLM
STAT- MEDLINE
DCOM- 20120724
LR  - 20211203
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Linking)
VI  - 27
IP  - 5
DP  - 2012 May
TI  - Linear nevus sebaceous syndrome with hypophosphatemic rickets with elevated 
      FGF-23.
PG  - 861-3
LID - 10.1007/s00467-011-2086-4 [doi]
AB  - BACKGROUND: Linear nevus sebaceous syndrome (LNSS) is a rare congenital 
      neuroectodermal disorder characterized by involvement of the skeleton and central 
      nervous system. CASE: We report the case of a 5-year-old girl who had LNSS with 
      hypophosphatemic rickets and multiple fractures of her extremities. Biochemical 
      tests revealed a high serum level of fibroblast growth factor-23 (FGF-23) but 
      normal levels of immunoglobulin E (IgE) and parathormone (PTH). FGF-23 mRNA 
      expression in the skin lesions of our patient's skin was found to be below the 
      limit of detection in all samples tested by quantitative-PCR analysis. 
      CONCLUSIONS: It is possible that an as-yet unidentified substance increases 
      FGF-23 expression LNS lesions.
FAU - Narazaki, Ryo
AU  - Narazaki R
AD  - Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 
      3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
FAU - Ihara, Kenji
AU  - Ihara K
FAU - Namba, Noriyuki
AU  - Namba N
FAU - Matsuzaki, Hiroshi
AU  - Matsuzaki H
FAU - Ozono, Keiichi
AU  - Ozono K
FAU - Hara, Toshiro
AU  - Hara T
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20111229
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (FGF23 protein, human)
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Phosphates)
RN  - 0 (RNA, Messenger)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 62031-54-3 (Fibroblast Growth Factors)
RN  - 7Q7P4S7RRE (Fibroblast Growth Factor-23)
RN  - P6YZ13C99Q (Calcifediol)
SB  - IM
MH  - Calcifediol/therapeutic use
MH  - Child, Preschool
MH  - Dietary Supplements
MH  - Familial Hypophosphatemic Rickets/*complications/*genetics/pathology
MH  - Female
MH  - Fibroblast Growth Factor-23
MH  - Fibroblast Growth Factors/*blood
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Nevus, Sebaceous of Jadassohn/*complications/*genetics/pathology
MH  - Parathyroid Hormone/blood
MH  - Phosphates/therapeutic use
MH  - Polymerase Chain Reaction
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Skin/metabolism/pathology
EDAT- 2011/12/30 06:00
MHDA- 2012/07/25 06:00
CRDT- 2011/12/30 06:00
PHST- 2011/08/18 00:00 [received]
PHST- 2011/11/24 00:00 [accepted]
PHST- 2011/11/24 00:00 [revised]
PHST- 2011/12/30 06:00 [entrez]
PHST- 2011/12/30 06:00 [pubmed]
PHST- 2012/07/25 06:00 [medline]
AID - 10.1007/s00467-011-2086-4 [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2012 May;27(5):861-3. doi: 10.1007/s00467-011-2086-4. Epub 2011 
      Dec 29.