PMID- 22205791
OWN - NLM
STAT- MEDLINE
DCOM- 20120710
LR  - 20211021
IS  - 1098-660X (Electronic)
IS  - 0095-1137 (Print)
IS  - 0095-1137 (Linking)
VI  - 50
IP  - 4
DP  - 2012 Apr
TI  - Individual Plasmodium vivax msp1 variants within polyclonal P. vivax infections 
      display different propensities for relapse.
PG  - 1449-51
LID - 10.1128/JCM.06212-11 [doi]
AB  - Using a newly developed Plasmodium vivax merozoite surface protein 1 gene 
      (Pvmsp1) heteroduplex tracking assay, we genotyped 107 P. vivax infections in 
      individuals from Cambodia, 45 of whom developed recurrent parasitemia within 42 
      days. The majority of isolates were polyclonal, but recurrent parasitemias 
      displayed fewer variants compared to initial parasitemias. Two Pvmsp1 gene 
      variants occurred more frequently in the initial genotypes of those who developed 
      recurrent parasitemia, representing the first time P. vivax variants associated 
      with a higher risk of relapse have been described.
FAU - Lin, Jessica T
AU  - Lin JT
AD  - Division of Infectious Diseases, University of North Carolina School of Medicine, 
      Chapel Hill, North Carolina, USA. jessica_lin@med.unc.edu
FAU - Juliano, Jonathan J
AU  - Juliano JJ
FAU - Kharabora, Oksana
AU  - Kharabora O
FAU - Sem, Rithy
AU  - Sem R
FAU - Lin, Feng-Chang
AU  - Lin FC
FAU - Muth, Sinuon
AU  - Muth S
FAU - Menard, Didier
AU  - Menard D
FAU - Wongsrichanalai, Chansuda
AU  - Wongsrichanalai C
FAU - Rogers, William O
AU  - Rogers WO
FAU - Meshnick, Steven R
AU  - Meshnick SR
LA  - eng
GR  - 5T32AI0715132/AI/NIAID NIH HHS/United States
GR  - T32 AI007151/AI/NIAID NIH HHS/United States
GR  - AI076785/AI/NIAID NIH HHS/United States
GR  - R01 AI089819/AI/NIAID NIH HHS/United States
GR  - AI089819/AI/NIAID NIH HHS/United States
GR  - R01 AI089819-02/AI/NIAID NIH HHS/United States
GR  - R21 AI076785/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120111
PL  - United States
TA  - J Clin Microbiol
JT  - Journal of clinical microbiology
JID - 7505564
RN  - 0 (Merozoite Surface Protein 1)
SB  - IM
MH  - Genetic Variation
MH  - Genotype
MH  - Genotyping Techniques
MH  - Humans
MH  - Malaria, Vivax/diagnosis/*parasitology/prevention & control
MH  - Merozoite Surface Protein 1/*genetics
MH  - Molecular Typing
MH  - Plasmodium vivax/*genetics
MH  - Recurrence
MH  - Sensitivity and Specificity
MH  - Young Adult
PMC - PMC3318509
EDAT- 2011/12/30 06:00
MHDA- 2012/07/11 06:00
PMCR- 2012/10/01
CRDT- 2011/12/30 06:00
PHST- 2011/12/30 06:00 [entrez]
PHST- 2011/12/30 06:00 [pubmed]
PHST- 2012/07/11 06:00 [medline]
PHST- 2012/10/01 00:00 [pmc-release]
AID - JCM.06212-11 [pii]
AID - 06212-11 [pii]
AID - 10.1128/JCM.06212-11 [doi]
PST - ppublish
SO  - J Clin Microbiol. 2012 Apr;50(4):1449-51. doi: 10.1128/JCM.06212-11. Epub 2012 
      Jan 11.