PMID- 22206732
OWN - NLM
STAT- MEDLINE
DCOM- 20120514
LR  - 20131121
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 92
DP  - 2012 Apr 1
TI  - Preparation and characterization of succinic acid deamidated wheat gluten 
      microspheres for encapsulation of fish oil.
PG  - 305-14
LID - 10.1016/j.colsurfb.2011.12.003 [doi]
AB  - Succinic acid deamidated wheat gluten (SDWG) microspheres for encapsulation of 
      fish oil (FO) via O/W/O double-emulsion followed by heat-polymerization of 
      emulsified SDWG was reported. Different SWDG concentrations (16.8-67.2 mg/ml) and 
      FO/SDWG ratios (1:3-4:3, w/w) were studied. To optimize the process, particle 
      size and Zeta potential of SDWG-FO emulsion and encapsulation efficiency (EE) of 
      FO were analyzed. The most efficient condition was obtained at 50.4 mg/ml for 
      SDWG and 3:3 (w/w) for FO/SDWG ratio, with an EE of 81.8%. In this condition, 
      confocal microscopy showed FO well encapsulated in SDWG microspheres. Scanning 
      electron microscope (SEM) showed sunken pores and fractures inside microspheres 
      after FO was extracted, confirming the presence of FO in microspheres. FTIR and 
      electrophoresis showed during microspheres formation dramatically elevated SWDG 
      aggregation resulted in intermolecular-crosslinking and enhanced interactions 
      (hydrogen bonds and hydrophobic interactions) between SDWG and FO. In the 
      evaluations of in vitro experiments in simulated gastric fluid and oxidation 
      stability during storage, results indicated that SDWG matrix protected it from 
      both oxygen and gastric fluid, resulting in improved storage stability and 
      release property. Therefore, it is foreseen that SDWG can be used to encapsulate 
      FO or other sensitive nutraceuticals in the applications of supplementation and 
      functional foods.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Liao, Lan
AU  - Liao L
AD  - Department of Nutrition and Food Sciences, University of Maryland, College Park, 
      MD 20742-7521, USA.
FAU - Luo, Yangchao
AU  - Luo Y
FAU - Zhao, Mouming
AU  - Zhao M
FAU - Wang, Qin
AU  - Wang Q
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20111213
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Amides)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Emulsions)
RN  - 0 (Fish Oils)
RN  - 8002-80-0 (Glutens)
RN  - AB6MNQ6J6L (Succinic Acid)
SB  - IM
MH  - Amides/*chemistry
MH  - Body Fluids/drug effects
MH  - Delayed-Action Preparations
MH  - Drug Compounding/*methods
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Emulsions
MH  - Fish Oils/*pharmacology
MH  - Glutens/*chemistry
MH  - Microscopy, Confocal
MH  - Microscopy, Electron, Scanning
MH  - *Microspheres
MH  - Oxidation-Reduction/drug effects
MH  - Particle Size
MH  - Protein Structure, Secondary
MH  - Static Electricity
MH  - Succinic Acid/*chemistry
MH  - Triticum/*chemistry
EDAT- 2011/12/31 06:00
MHDA- 2012/05/15 06:00
CRDT- 2011/12/31 06:00
PHST- 2011/08/03 00:00 [received]
PHST- 2011/11/01 00:00 [revised]
PHST- 2011/12/05 00:00 [accepted]
PHST- 2011/12/31 06:00 [entrez]
PHST- 2011/12/31 06:00 [pubmed]
PHST- 2012/05/15 06:00 [medline]
AID - S0927-7765(11)00737-5 [pii]
AID - 10.1016/j.colsurfb.2011.12.003 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2012 Apr 1;92:305-14. doi: 
      10.1016/j.colsurfb.2011.12.003. Epub 2011 Dec 13.