PMID- 22206815
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20181201
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 677
IP  - 1-3
DP  - 2012 Feb 29
TI  - Pramipexole is active in depression tests and modulates monoaminergic 
      transmission, but not brain levels of BDNF in mice.
PG  - 77-86
LID - 10.1016/j.ejphar.2011.12.014 [doi]
AB  - The dopamine D(2)/D(3) receptor agonist pramipexole exerts antidepressive 
      capacities in patients with Parkinson's disease with little evidence for patients 
      with affective diseases only. Little is known about the neurobiological basis of 
      these antidepressive effects. In this study, C57BL/6N mice received acute or 
      chronic (3 weeks) treatment with pramipexole in different dosages (0.1, 0.3, 1, 
      and 3mg/kg b.w.) and imipramine or saline serving as positive and negative 
      controls. To characterize antidepressant-like effects mice underwent behavioral 
      characterization. In a second experiment dosages of pramipexole shown to be 
      effective were used and candidate brain regions including hippocampus, frontal 
      cortex and striatum were analyzed for levels of 5-hydroxytryptamine (5-HT), 
      noradrenaline and dopamine and their metabolites as well as brain-derived 
      neurotrophic factor (BDNF) to investigate possible neurochemical correlates of 
      behavioral changes. Whereas acute treatment with pramipexole resulted in 
      antidepressive-like effects in the Porsolt Forced Swim Test, Novel Cage Test, 
      Openfield Test and Dark-light-Box Test and a tendency but insignificant effect in 
      the Tail Suspension Test, chronic treatment did not show significant effects in 
      any of the behavioral analyses. Neurochemical analyses revealed a highly 
      significant effect on dopaminergic metabolites in the striatum as well as a 
      moderate transient modulation of the serotonergic system in the hippocampus. BDNF 
      levels were not affected by any dosage and treatment regime in any brain region 
      investigated. In conclusion, the present data substantiate antidepressive effects 
      of pramipexole and indicate a contribution of the dopaminergic and serotonergic 
      metabolism in these effects, but argue against an eminent role of BDNF.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Schulte-Herbruggen, Olaf
AU  - Schulte-Herbruggen O
AD  - Department of Psychiatry and Psychotherapy, Charite-University Medicine Berlin, 
      Campus Charite Mitte, Berlin, Germany.
FAU - Vogt, Miriam A
AU  - Vogt MA
FAU - Hortnagl, Heide
AU  - Hortnagl H
FAU - Gass, Peter
AU  - Gass P
FAU - Hellweg, Rainer
AU  - Hellweg R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111222
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Antidepressive Agents)
RN  - 0 (Benzothiazoles)
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dopamine Agonists)
RN  - 83619PEU5T (Pramipexole)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/pharmacology/therapeutic use
MH  - Behavior, Animal/drug effects
MH  - Benzothiazoles/*pharmacology/therapeutic use
MH  - Biogenic Monoamines/*metabolism
MH  - Brain/*drug effects/metabolism/pathology/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depression/*drug therapy/metabolism/pathology/physiopathology
MH  - Dopamine Agonists/pharmacology/therapeutic use
MH  - Emotions/drug effects
MH  - Hindlimb Suspension
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neuronal Plasticity/drug effects
MH  - Pramipexole
MH  - Synaptic Transmission/*drug effects
MH  - Time Factors
EDAT- 2011/12/31 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/12/31 06:00
PHST- 2011/06/22 00:00 [received]
PHST- 2011/11/28 00:00 [revised]
PHST- 2011/12/07 00:00 [accepted]
PHST- 2011/12/31 06:00 [entrez]
PHST- 2011/12/31 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - S0014-2999(11)01533-0 [pii]
AID - 10.1016/j.ejphar.2011.12.014 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2012 Feb 29;677(1-3):77-86. doi: 10.1016/j.ejphar.2011.12.014. 
      Epub 2011 Dec 22.