PMID- 22207209
OWN - NLM
STAT- MEDLINE
DCOM- 20120613
LR  - 20131121
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 139
IP  - 3
DP  - 2012 Feb 15
TI  - Extract of Ganoderma lucidum prolongs sleep time in rats.
PG  - 796-800
LID - 10.1016/j.jep.2011.12.020 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Ling Zhi) is a basidiomycete 
      white-rot macrofungus that has been used as a tranquilizing agent (i.e., An-Shen 
      effect) for the treatment of restlessness, insomnia, and palpitation in China for 
      hundreds of years. AIM OF THE STUDY: The present study aimed to investigate 
      whether Ganoderma lucidum extract (GLE) influences the sleep of freely moving 
      rats and the potential mechanism. MATERIALS AND METHODS: Ganoderma lucidum 
      extract was extracted from fruiting bodies of Ganoderma lucidum. Rats were 
      treated with GLE orally for 3 days, and on the third day, electroencephalographic 
      and electromyographic recordings were made for 6h from 9:00 p.m. to 3:00 a.m. in 
      freely moving rats. Sleep parameters were analyzed using SleepSign software. 
      Tumor necrosis factor-alpha (TNF-alpha) levels were measured using the enzyme-linked 
      immunosorbent assay. RESULTS: Three-day administration of GLE significantly 
      increased total sleep time and non-rapid eye movement (NREM) sleep time at a dose 
      of 80 mg/kg (i.g.) without influencing slow-wave sleep or REM sleep in freely 
      moving rats. TNF-alpha levels were significantly increased concomitantly in serum, 
      the hypothalamus, and dorsal raphe nucleus. The hypnotic effect of GLE (80 mg/kg, 
      i.g.) was significantly inhibited by intracerebroventricular injection of TNF-alpha 
      antibody (2.5 mug/rat). Co-administration of GLE (40 mg/kg, i.g.) and TNF-alpha (12.5 
      ng/rat, i.c.v.), both at ineffective doses, revealed an additive hypnotic effect. 
      CONCLUSION: These results suggest that GLE has hypnotic effects in freely moving 
      rats. The mechanism by which the extract promoted sleep remains unclear, but this 
      effect appears to be primarily related to the modulation of cytokines such as 
      TNF-alpha. Furthermore, these data at least partially support the ethnomedical use of 
      Ganoderma lucidum.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Cui, Xiang-Yu
AU  - Cui XY
AD  - Department of Pharmacology, Peking University, School of Basic Medical Science, 
      Beijing, China.
FAU - Cui, Su-Ying
AU  - Cui SY
FAU - Zhang, Juan
AU  - Zhang J
FAU - Wang, Zi-Jun
AU  - Wang ZJ
FAU - Yu, Bin
AU  - Yu B
FAU - Sheng, Zhao-Fu
AU  - Sheng ZF
FAU - Zhang, Xue-Qiong
AU  - Zhang XQ
FAU - Zhang, Yong-He
AU  - Zhang YH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111221
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Biological Products)
RN  - 0 (Hypnotics and Sedatives)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Biological Products/*pharmacology/therapeutic use
MH  - Drug Synergism
MH  - Fruiting Bodies, Fungal
MH  - *Ganoderma
MH  - Hypnotics and Sedatives/*pharmacology/therapeutic use
MH  - Male
MH  - Phytotherapy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sleep/*drug effects
MH  - Sleep Initiation and Maintenance Disorders/drug therapy
MH  - Sleep, REM/drug effects
MH  - Tumor Necrosis Factor-alpha/*metabolism/pharmacology
EDAT- 2011/12/31 06:00
MHDA- 2012/06/14 06:00
CRDT- 2011/12/31 06:00
PHST- 2011/07/08 00:00 [received]
PHST- 2011/12/05 00:00 [revised]
PHST- 2011/12/13 00:00 [accepted]
PHST- 2011/12/31 06:00 [entrez]
PHST- 2011/12/31 06:00 [pubmed]
PHST- 2012/06/14 06:00 [medline]
AID - S0378-8741(11)00898-1 [pii]
AID - 10.1016/j.jep.2011.12.020 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2012 Feb 15;139(3):796-800. doi: 10.1016/j.jep.2011.12.020. 
      Epub 2011 Dec 21.