PMID- 22209087
OWN - NLM
STAT- MEDLINE
DCOM- 20120511
LR  - 20120217
IS  - 1872-9142 (Electronic)
IS  - 0161-5890 (Linking)
VI  - 50
IP  - 1-2
DP  - 2012 Feb
TI  - Analysis of genes regulated by the transcription factor LUMAN identifies ApoA4 as 
      a target gene in dendritic cells.
PG  - 66-73
LID - 10.1016/j.molimm.2011.12.003 [doi]
AB  - Dendritic cells (DCs) are professional antigen presenting cells of the immune 
      system that play a crucial role in initiating immune responses and maintaining 
      self tolerance. Better understanding of the molecular basis of DC immunobiology 
      is required to improve DC-based immunotherapies. We previously described the 
      interaction of transcription factor LUMAN (also known as CREB3 or LZIP) with the 
      DC-specific transmembrane protein DC-STAMP in DCs. Target genes of LUMAN and its 
      role in DCs are currently unknown. In this study we set out to identify genes 
      regulated by LUMAN in DCs using microarray analysis. Expression of a 
      constitutively active form of LUMAN in mouse DC cell line D2SC/1 identified 
      Apolipoprotein A4 (ApoA4) as its target gene. Subsequent validation experiments, 
      bioinformatics-based promoter analysis, and silencing studies confirmed that 
      ApoA4 is a true target gene of LUMAN in bone marrow-derived DCs (BMDCs).
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Sanecka, Anna
AU  - Sanecka A
AD  - Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, 
      Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
FAU - Ansems, Marleen
AU  - Ansems M
FAU - van Hout-Kuijer, Maaike A
AU  - van Hout-Kuijer MA
FAU - Looman, Maaike W G
AU  - Looman MW
FAU - Prosser, Amy C
AU  - Prosser AC
FAU - Welten, Suzanne
AU  - Welten S
FAU - Gilissen, Christian
AU  - Gilissen C
FAU - Sama, Iziah E
AU  - Sama IE
FAU - Huynen, Martijn A
AU  - Huynen MA
FAU - Veltman, Joris A
AU  - Veltman JA
FAU - Jansen, Bastiaan J H
AU  - Jansen BJ
FAU - Eleveld-Trancikova, Dagmar
AU  - Eleveld-Trancikova D
FAU - Adema, Gosse J
AU  - Adema GJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111230
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (Apolipoproteins A)
RN  - 0 (Creb3 protein, mouse)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Protein Synthesis Inhibitors)
RN  - 0 (apolipoprotein A-IV)
RN  - 20350-15-6 (Brefeldin A)
SB  - IM
MH  - Animals
MH  - Apolipoproteins A/*genetics
MH  - Bone Marrow Cells/drug effects/metabolism
MH  - Brefeldin A/pharmacology
MH  - Cell Line
MH  - Cells, Cultured
MH  - Cyclic AMP Response Element-Binding Protein/*genetics
MH  - Dendritic Cells/drug effects/*metabolism
MH  - Female
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation
MH  - HEK293 Cells
MH  - Humans
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - NIH 3T3 Cells
MH  - Oligonucleotide Array Sequence Analysis
MH  - Protein Synthesis Inhibitors/pharmacology
MH  - RNA Interference
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2012/01/03 06:00
MHDA- 2012/05/12 06:00
CRDT- 2012/01/03 06:00
PHST- 2011/08/12 00:00 [received]
PHST- 2011/12/09 00:00 [revised]
PHST- 2011/12/11 00:00 [accepted]
PHST- 2012/01/03 06:00 [entrez]
PHST- 2012/01/03 06:00 [pubmed]
PHST- 2012/05/12 06:00 [medline]
AID - S0161-5890(11)00826-1 [pii]
AID - 10.1016/j.molimm.2011.12.003 [doi]
PST - ppublish
SO  - Mol Immunol. 2012 Feb;50(1-2):66-73. doi: 10.1016/j.molimm.2011.12.003. Epub 2011 
      Dec 30.