PMID- 2221018
OWN - NLM
STAT- MEDLINE
DCOM- 19901114
LR  - 20181113
IS  - 0002-9440 (Print)
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Linking)
VI  - 137
IP  - 4
DP  - 1990 Oct
TI  - MaxEPA fish oil enhances cholesterol-induced intimal foam cell formation in 
      rabbits.
PG  - 945-51
AB  - In this study, the cholesterol-fed rabbit model was used to test the hypothesis 
      that fish oil supplementation can influence the initiation and development of 
      atherosclerotic lesions. Rabbits were fed one of two diets for a period of 30 
      days: a nonatherogenic diet with corn oil as the sole fat source, or an 
      atherogenic diet containing beef tallow and cholesterol. In addition, animals 
      received a daily supplement of either MaxEPA fish oil or corn oil (0.5 ml/kg body 
      weight). Terminal blood samples were drawn and the cholesterol and triglyceride 
      levels determined for both plasma and very low-density (VLDL), 
      intermediate-density (IDL), low-density (LDL), and high-density (HDL) 
      lipoproteins. Thiobarbituric acid-reacting substance (TBARS), an indicator of 
      lipid peroxidation, was measured in the plasma samples. Besides these biochemical 
      parameters of atherogenesis, the number of intimal foam cells in the descending 
      thoracic aorta of each animal was determined by microscopic examination of the 
      vessels en face. In rabbits fed the nonatherogenic diet, fish oil supplementation 
      did not significantly affect any of the biochemical parameters that were 
      measured. In contrast, fish oil supplementation of the atherogenic diet led to a 
      significant increase in the LDL- and HDL-cholesterol as well as the 
      HDL-triglyceride levels. Plasma TBARS also increased more than four times. 
      Morphologic analysis of the vessels from rabbits fed the atherogenic diet 
      indicated that fish oil supplementation led to a threefold increase in the number 
      of intimal foam cells, a result that may be linked to increases in both 
      LDL-cholesterol and plasma TBARS. The results of these experiments do not support 
      the hypothesis that dietary fish oil will inhibit the initiation or progression 
      of lesion formation in the cholesterol-fed rabbit.
FAU - Rogers, K A
AU  - Rogers KA
AD  - Department of Anatomy, University of Western Ontario, London, Canada.
FAU - Adelstein, R
AU  - Adelstein R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (Cholesterol, Dietary)
RN  - 0 (Dietary Fats)
RN  - 0 (Fish Oils)
RN  - 0 (Lipoproteins)
RN  - 0 (Thiobarbiturates)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - M1YZW5SS7C (thiobarbituric acid)
SB  - IM
MH  - Animals
MH  - Cholesterol/blood
MH  - Cholesterol, Dietary/*adverse effects
MH  - *Diet, Atherogenic
MH  - Dietary Fats/*pharmacology
MH  - Endothelium, Lymphatic/*drug effects/pathology
MH  - Female
MH  - Fish Oils/*pharmacology
MH  - Foam Cells/pathology
MH  - Lipoproteins/blood
MH  - Rabbits
MH  - Thiobarbiturates
MH  - Triglycerides/blood
PMC - PMC1877556
EDAT- 1990/10/01 00:00
MHDA- 1990/10/01 00:01
PMCR- 1991/04/01
CRDT- 1990/10/01 00:00
PHST- 1990/10/01 00:00 [pubmed]
PHST- 1990/10/01 00:01 [medline]
PHST- 1990/10/01 00:00 [entrez]
PHST- 1991/04/01 00:00 [pmc-release]
PST - ppublish
SO  - Am J Pathol. 1990 Oct;137(4):945-51.