PMID- 22210909
OWN - NLM
STAT- MEDLINE
DCOM- 20120611
LR  - 20220309
IS  - 1550-6606 (Electronic)
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 188
IP  - 3
DP  - 2012 Feb 1
TI  - Early responding dendritic cells direct the local NK response to control herpes 
      simplex virus 1 infection within the cornea.
PG  - 1350-9
LID - 10.4049/jimmunol.1101968 [doi]
AB  - Dendritic cells (DCs) regulate both innate and adaptive immune responses. In this 
      article, we exploit the unique avascularity of the cornea to examine a role for 
      local or very early infiltrating DCs in regulating the migration of blood-derived 
      innate immune cells toward HSV-1 lesions. A single systemic diphtheria toxin 
      treatment 2 d before HSV-1 corneal infection transiently depleted CD11c(+) DCs 
      from both the cornea and lymphoid organs of CD11c-DTR bone marrow chimeric mice 
      for up to 24 h postinfection. Transient DC depletion significantly delayed HSV-1 
      clearance from the cornea through 6 d postinfection. No further compromise of 
      viral clearance was observed when DCs were continuously depleted throughout the 
      first week of infection. DC depletion did not influence extravasation of NK 
      cells, inflammatory monocytes, or neutrophils into the peripheral cornea, but it 
      did significantly reduce migration of NK cells and inflammatory monocytes, but 
      not neutrophils, toward the HSV-1 lesion in the central cornea. Depletion of NK 
      cells resulted in similar loss of viral control to transient DC ablation. Our 
      findings demonstrate that resident corneal DCs and/or those that infiltrate the 
      cornea during the first 24 h after HSV-1 infection contribute to the migration of 
      NK cells and inflammatory monocytes into the central cornea, and are consistent 
      with a role for NK cells and possibly inflammatory monocytes, but not 
      polymorphonuclear neutrophils, in clearing HSV-1 from the infected cornea.
FAU - Frank, Gregory M
AU  - Frank GM
AD  - Graduate Program in Immunology, University of Pittsburgh School of Medicine, 
      Pittsburgh, PA 15213, USA.
FAU - Buela, Kristine-Ann G
AU  - Buela KA
FAU - Maker, Dawn M
AU  - Maker DM
FAU - Harvey, Stephen A K
AU  - Harvey SA
FAU - Hendricks, Robert L
AU  - Hendricks RL
LA  - eng
SI  - GEO/GSE33991
GR  - T32 EY017271-04/EY/NEI NIH HHS/United States
GR  - P30 EY008098-23/EY/NEI NIH HHS/United States
GR  - T32 EY017271-05/EY/NEI NIH HHS/United States
GR  - P30-EY08099/EY/NEI NIH HHS/United States
GR  - R01 EY010359-17S1/EY/NEI NIH HHS/United States
GR  - P30 EY008098-24/EY/NEI NIH HHS/United States
GR  - R01 EY010359/EY/NEI NIH HHS/United States
GR  - R01 EY010359-16/EY/NEI NIH HHS/United States
GR  - T32 EY017271-03/EY/NEI NIH HHS/United States
GR  - R01 EY010359-17/EY/NEI NIH HHS/United States
GR  - T32 EY017271/EY/NEI NIH HHS/United States
GR  - R01-EY010359/EY/NEI NIH HHS/United States
GR  - 5T32-EY017271-02/EY/NEI NIH HHS/United States
GR  - P30 EY008098-22/EY/NEI NIH HHS/United States
GR  - P30 EY008098/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111230
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
SB  - IM
MH  - Animals
MH  - Cell Movement/immunology
MH  - Cornea/virology
MH  - Corneal Diseases/immunology/*virology
MH  - Dendritic Cells/*immunology/virology
MH  - Herpesvirus 1, Human/*immunology
MH  - Immunity, Innate/immunology
MH  - Killer Cells, Natural/*immunology/virology
MH  - Mice
MH  - Monocytes/immunology
MH  - Neutrophils/immunology
PMC - PMC3292873
MID - NIHMS342582
EDAT- 2012/01/03 06:00
MHDA- 2012/06/12 06:00
PMCR- 2013/02/01
CRDT- 2012/01/03 06:00
PHST- 2012/01/03 06:00 [entrez]
PHST- 2012/01/03 06:00 [pubmed]
PHST- 2012/06/12 06:00 [medline]
PHST- 2013/02/01 00:00 [pmc-release]
AID - jimmunol.1101968 [pii]
AID - 10.4049/jimmunol.1101968 [doi]
PST - ppublish
SO  - J Immunol. 2012 Feb 1;188(3):1350-9. doi: 10.4049/jimmunol.1101968. Epub 2011 Dec 
      30.