PMID- 22211527
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20221207
IS  - 1346-8138 (Electronic)
IS  - 0385-2407 (Linking)
VI  - 39
IP  - 7
DP  - 2012 Jul
TI  - HLA-A31 strongly associates with carbamazepine-induced adverse drug reactions but 
      not with carbamazepine-induced lymphocyte proliferation in a Japanese population.
PG  - 594-601
LID - 10.1111/j.1346-8138.2011.01457.x [doi]
AB  - Carbamazepine (CBZ) is the most frequent culprit drug for severe cutaneous 
      adverse drug reactions (ADR), such as Stevens-Johnson syndrome (SJS), toxic 
      epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS). A 
      strong association between human leukocyte antigen (HLA)-B*1502 and CBZ-induced 
      SJS/TEN has been reported in Han Chinese, Thai, Malaysian and Indian populations, 
      but not in Caucasian or Japanese populations. Recent studies showed an 
      association between HLA-A*3101 and CBZ-induced ADR in Caucasian and Japanese 
      populations. We conducted a case-control study to determine HLA genotyping of 
      patients with CBZ-induced ADR in a Japanese population. Fifteen patients with 
      CBZ-induced ADR and 33 subjects who had taken CBZ for more than 3 months without 
      evidence of any ADR as a control were enrolled. In addition, the results of a 
      CBZ-induced lymphocyte stimulation test were compared between the groups. A 
      strong association was found between HLA-A31 and CBZ-induced ADR (P < 0.001), and 
      a weak association was found between HLA-A11 and HLA-B51 with CBZ-induced ADR. No 
      HLA-B*1502 was found in either patients or control subjects. The mean CBZ-induced 
      lymphocyte stimulation index was significantly high in patients with CBZ-induced 
      ADR compared with CBZ-tolerant patients (P < 0.001); however, no significant 
      difference was seen between HLA-A31-positive subjects and HLA-A31-negative 
      subjects in either group. These findings suggest that HLA-A31 is strongly 
      associated with CBZ-induced ADR in the Japanese, but does not determine 
      CBZ-induced lymphocyte proliferation.
CI  - (c) 2011 Japanese Dermatological Association.
FAU - Niihara, Hiroyuki
AU  - Niihara H
AD  - Department of Dermatology, Shimane University, Izumo, Shimane, Japan. 
      ofcourse@med.shimane-u.ac.jp
FAU - Kakamu, Takeyasu
AU  - Kakamu T
FAU - Fujita, Yasuyuki
AU  - Fujita Y
FAU - Kaneko, Sakae
AU  - Kaneko S
FAU - Morita, Eishin
AU  - Morita E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111229
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
RN  - 0 (Anticonvulsants)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A31 antigen)
RN  - 33CM23913M (Carbamazepine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amino Acid Sequence
MH  - Anticonvulsants/adverse effects/immunology
MH  - Asian People/genetics
MH  - Carbamazepine/*adverse effects/immunology
MH  - Case-Control Studies
MH  - Drug Eruptions/*genetics/*immunology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - HLA-A Antigens/*genetics
MH  - Humans
MH  - Japan
MH  - Lymphocyte Activation/drug effects
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Stevens-Johnson Syndrome/chemically induced/genetics/immunology
MH  - Young Adult
EDAT- 2012/01/04 06:00
MHDA- 2012/10/26 06:00
CRDT- 2012/01/04 06:00
PHST- 2012/01/04 06:00 [entrez]
PHST- 2012/01/04 06:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
AID - 10.1111/j.1346-8138.2011.01457.x [doi]
PST - ppublish
SO  - J Dermatol. 2012 Jul;39(7):594-601. doi: 10.1111/j.1346-8138.2011.01457.x. Epub 
      2011 Dec 29.