PMID- 22211844
OWN - NLM
STAT- MEDLINE
DCOM- 20120813
LR  - 20151119
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 101
IP  - 5
DP  - 2012 May
TI  - Markers of systemic inflammation in children with hyperuricemia.
PG  - 497-500
LID - 10.1111/j.1651-2227.2011.02582.x [doi]
AB  - AIM: The purpose of the study was to investigate serum concentrations of the 
      monocyte chemoattractant protein-1 (MCP-1) and high-sensitivity CRP (hs-CRP) in 
      children with hyperuricemia and to evaluate its association with obesity. 
      PATIENTS AND METHODS: The study involved 52 hyperuricemic patients with mean age 
      of 15.53 +/- 1.7 years. Twenty-seven healthy individuals with normal serum uric 
      acid (SUA) level were selected as the control group (C). Serum MCP-1 and hs-CRP 
      were measured by enzyme-linked immunosorbent assay (ELISA) and 
      immunonephelometry, respectively. RESULTS: Hyperuricemic patients showed 
      increased sMCP-1 (median: 69.58 pg/mL) and hs-CRP (median: 0.53 mg/L) vs. 
      controls (48.39 pg/mL, 0.24 mg/L; respectively) (p < 0.01). The obese children 
      also presented significantly higher levels of sMCP-1 and hs-CRP (median, 81.69 
      and 1.18 mg/L, respectively) in comparison with nonobese (median, 59.62 and 0.41 
      mg/L, respectively; p < 0.01). Only hs-CRP correlated positively with body mass 
      index Z-score (r = 0.33, p < 0.05). Receiver operator characteristic analyses 
      checking the sensitivity and specificity of examined markers for hyperuricemia 
      revealed the higher area under the curve (AUC) for sMCP-1; however, the 
      difference between AUC for sMCP-1 and for hs-CRP was not significant (p > 0.05). 
      CONCLUSION: Serum MCP-1 and hs-CRP are elevated in hyperuricemic patients, but 
      the role of obesity in inflammation markers needs further investigation.
CI  - (c) 2011 The Author(s)/Acta Paediatrica (c) 2011 Foundation Acta Paediatrica.
FAU - Wasilewska, Anna
AU  - Wasilewska A
AD  - Department of Pediatrics and Nephrology, Medical University of Bialystok, 
      Bialystok, Poland. annwasil@interia.pl
FAU - Tenderenda, Edyta
AU  - Tenderenda E
FAU - Taranta-Janusz, Katarzyna
AU  - Taranta-Janusz K
FAU - Tobolczyk, Jolanta
AU  - Tobolczyk J
FAU - Stypulkowska, Justyna
AU  - Stypulkowska J
LA  - eng
PT  - Journal Article
DEP - 20120223
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 268B43MJ25 (Uric Acid)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
CIN - Acta Paediatr. 2012 May;101(5):e195; author reply e195-6. PMID: 22296343
MH  - Adolescent
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*analysis
MH  - Chemokine CCL2/*blood
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Hyperuricemia/*blood/complications
MH  - Inflammation/*blood/complications
MH  - Male
MH  - Obesity/blood/complications
MH  - Uric Acid/blood
EDAT- 2012/01/04 06:00
MHDA- 2012/08/14 06:00
CRDT- 2012/01/04 06:00
PHST- 2012/01/04 06:00 [entrez]
PHST- 2012/01/04 06:00 [pubmed]
PHST- 2012/08/14 06:00 [medline]
AID - 10.1111/j.1651-2227.2011.02582.x [doi]
PST - ppublish
SO  - Acta Paediatr. 2012 May;101(5):497-500. doi: 10.1111/j.1651-2227.2011.02582.x. 
      Epub 2012 Feb 23.