PMID- 22211929
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20141120
IS  - 1556-4029 (Electronic)
IS  - 0022-1198 (Linking)
VI  - 57
IP  - 4
DP  - 2012 Jul
TI  - Interaction of 3,4-methylenedioxymethamphetamine and methamphetamine during 
      metabolism by in vitro human metabolic enzymes and in rats.
PG  - 1008-13
LID - 10.1111/j.1556-4029.2011.02039.x [doi]
AB  - Illicit amphetamine-type stimulant (ATS) tablets commonly contain one or more 
      active ingredients, which have hallucinogenic and/or stimulant effects. Because 
      components such as 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine 
      (MA) in ATS tablets have similar chemical structures, they could be metabolized 
      by common metabolic enzymes. To investigate potential metabolic interactions of 
      ATS tablet components, we studied the in vitro metabolism of MDMA and MA using 
      human metabolic enzymes. MDMA and MA were mainly metabolized by cytochrome P450 
      2D6 (CYP2D6) and mutually inhibited the production of their main metabolites. In 
      vivo experiments were also performed using intravenous administration of MDMA, 
      MA, or their mixture to rats. The plasma concentrations of MDMA and MA after 
      co-administration were higher than those after administration of MDMA or MA 
      alone. The results in this study imply that multiple components in ATS tablets 
      can interact to mutually inhibit their metabolism and potentially enhance the 
      toxicity of each component.
CI  - (c) 2011 American Academy of Forensic Sciences.
FAU - Kuwayama, Kenji
AU  - Kuwayama K
AD  - National Research Institute of Police Science, Kashiwa, Chiba, Japan. 
      kuwayama@nrips.go.jp
FAU - Tsujikawa, Kenji
AU  - Tsujikawa K
FAU - Miyaguchi, Hajime
AU  - Miyaguchi H
FAU - Kanamori, Tatsuyuki
AU  - Kanamori T
FAU - Iwata, Yuko T
AU  - Iwata YT
FAU - Inoue, Hiroyuki
AU  - Inoue H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111228
PL  - United States
TA  - J Forensic Sci
JT  - Journal of forensic sciences
JID - 0375370
RN  - 0 (Hallucinogens)
RN  - 117652-28-5 (4-hydroxy-3-methoxymethamphetamine)
RN  - 44RAL3456C (Methamphetamine)
RN  - AY28O44JGD (pholedrine)
RN  - EC 1.13.- (Oxygenases)
RN  - EC 1.14.13.8 (dimethylaniline monooxygenase (N-oxide forming))
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP2D6)
RN  - EC 1.4.3.4 (Monoamine Oxidase)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Biotransformation
MH  - Cytochrome P-450 CYP2D6/*metabolism
MH  - Cytosol/metabolism
MH  - Drug Interactions
MH  - Forensic Toxicology
MH  - Hallucinogens/blood/*pharmacokinetics
MH  - Humans
MH  - In Vitro Techniques
MH  - Male
MH  - Methamphetamine/analogs & derivatives/blood/*pharmacokinetics
MH  - Microsomes/metabolism
MH  - Monoamine Oxidase/metabolism
MH  - N-Methyl-3,4-methylenedioxyamphetamine/blood/*pharmacokinetics
MH  - Oxygenases/metabolism
MH  - Rats
MH  - Rats, Wistar
EDAT- 2012/01/04 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/01/04 06:00
PHST- 2012/01/04 06:00 [entrez]
PHST- 2012/01/04 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1111/j.1556-4029.2011.02039.x [doi]
PST - ppublish
SO  - J Forensic Sci. 2012 Jul;57(4):1008-13. doi: 10.1111/j.1556-4029.2011.02039.x. 
      Epub 2011 Dec 28.