PMID- 22212273
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20170126
IS  - 0022-4707 (Print)
IS  - 0022-4707 (Linking)
VI  - 51
IP  - 4
DP  - 2011 Dec
TI  - Peroxisomal proliferator-activated receptor gamma co-activator-1 alpha gene 
      expression increases above the lactate threshold in human skeletal muscle.
PG  - 683-8
AB  - AIM: Peroxisomal proliferator-activated receptor gamma co-activator-1 alpha 
      (PGC-1alpha) plays a role not only as an activator of mitochondrial biogenesis, but 
      also as a suppressor of inflammatory cytokines, which induce chronic diseases. 
      Therefore, increasing PGC-1alpha expression can be one of the important factors for 
      preventing chronic diseases. PGC-1alpha expression is activated by adenosine 
      monophosphate-activated protein kinase (AMPK) and cAMP dependent kinase. The 
      activity of these enzymes depends on the exercise intensity. Therefore, this 
      study compared the effects of two different exercise intensities (above lactate 
      threshold (LT) and below LT) with an equal amount of energy expenditure on PGC-1alpha 
      gene expression in human skeletal muscle. METHODS: Six young men participated in 
      this study. They performed exercise at 120% and 80% LT intensity. The duration of 
      the 120% LT exercise was 60 minutes and the duration of the session performed at 
      80% LT was calculated to yield equal energy expenditure as the 120% LT intensity 
      exercise. Skeletal muscle was obtained after 1 hour of exercise. RESULTS: The 
      working rate, % peak VO2 and HR during exercise were significantly higher in at 
      120% LT than at 80% LT. PGC-1alpha gene expression was not significantly different 
      between control (0.087; 0.026-0.284 (the median; inter quartile range)) and 80% 
      LT (0.171; 0.030-0.484). However, PGC-1alpha gene expression after 120% LT (0.441; 
      0.121-4.643) was significantly higher than in the control. CONCLUSION: The 
      findings of this study suggest that PGC-1alpha gene expression depends on exercise 
      intensity.
FAU - Tobina, T
AU  - Tobina T
AD  - Fukuoka University, Fukuoka, Japan. tobitaku@ck9.so-net.ne.jp
FAU - Yoshioka, K
AU  - Yoshioka K
FAU - Hirata, A
AU  - Hirata A
FAU - Mori, S
AU  - Mori S
FAU - Kiyonaga, A
AU  - Kiyonaga A
FAU - Tanaka, H
AU  - Tanaka H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - J Sports Med Phys Fitness
JT  - The Journal of sports medicine and physical fitness
JID - 0376337
RN  - 0 (Heat-Shock Proteins)
RN  - 0 (PPARGC1A protein, human)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adult
MH  - *Anaerobic Threshold
MH  - Energy Metabolism
MH  - Exercise Test
MH  - *Gene Expression
MH  - Heart Rate
MH  - Heat-Shock Proteins/*genetics/*physiology
MH  - Humans
MH  - Male
MH  - Muscle, Skeletal/*physiology
MH  - Oxygen Consumption
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
MH  - Physical Exertion/*genetics/physiology
MH  - Transcription Factors/*genetics/*physiology
MH  - Young Adult
EDAT- 2012/01/04 06:00
MHDA- 2012/05/02 06:00
CRDT- 2012/01/04 06:00
PHST- 2012/01/04 06:00 [entrez]
PHST- 2012/01/04 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
AID - R40113285 [pii]
PST - ppublish
SO  - J Sports Med Phys Fitness. 2011 Dec;51(4):683-8.