PMID- 22212601
OWN - NLM
STAT- MEDLINE
DCOM- 20130909
LR  - 20171116
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 23
IP  - 4
DP  - 2013 Apr
TI  - Soluble receptor for advanced glycation end-product levels are related to 
      albuminuria and arterial stiffness in essential hypertension.
PG  - 382-8
LID - S0939-4753(11)00237-7 [pii]
LID - 10.1016/j.numecd.2011.10.003 [doi]
AB  - BACKGROUND AND AIMS: Emerging evidence suggests that the soluble receptor for 
      advanced glycation end-products (sRAGE) is implicated in the development of 
      vascular disease. We investigated the interrelationships of sRAGE with albumin to 
      creatinine ratio (ACR) and arterial stiffness in essential hypertension. METHODS 
      AND RESULTS: In 309 untreated non-diabetic hypertensives, ACR values were 
      determined as the mean of three non-consecutive morning spot urine samples and 
      aortic stiffness was evaluated on the basis of carotid to femoral pulse wave 
      velocity (c-f PWV). In all subjects, venous blood sampling was performed for the 
      estimation of sRAGE levels. Patients with low (n = 155) compared to those with 
      high sRAGE values (n = 154) had greater 24-h systolic BP (140 +/- 8 vs. 134 +/- 7 
      mmHg, p < 0.0001), exhibited higher ACR (36.3 +/- 51.6 vs. 17.2 +/- 1.2 mg g(-1), p < 
      0.0001) and c-f PWV (8.3 +/- 1.5 vs. 7.8 +/- 1.1 m s(-1), p = 0.003), independently 
      of confounding factors. Multiple regression analyses revealed that age, male sex, 
      24-h systolic BP and sRAGE were the 'independent correlates' of ACR (R(2) = 
      0.493, p < 0.0001), while age, 24-h systolic BP and sRAGE were the 'independent 
      correlates' of c-f PWV (R(2) = 0.428, p < 0.0001). CONCLUSION: In hypertensives, 
      decreased sRAGE levels are accompanied by pronounced albuminuria and arterial 
      stiffening. The association of sRAGE with ACR and c-f PWV suggests involvement of 
      sRAGE in the progression of hypertensive vascular damage.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Dimitriadis, K
AU  - Dimitriadis K
AD  - First Cardiology Clinic, University of Athens, Hippokration Hospital, 3 
      Kolokotroni Street, 15236 P.Panteli, Athens, Greece.
FAU - Tsioufis, C
AU  - Tsioufis C
FAU - Kasiakogias, A
AU  - Kasiakogias A
FAU - Miliou, A
AU  - Miliou A
FAU - Poulakis, M
AU  - Poulakis M
FAU - Kintis, K
AU  - Kintis K
FAU - Bafakis, I
AU  - Bafakis I
FAU - Benardis, E
AU  - Benardis E
FAU - Tousoulis, D
AU  - Tousoulis D
FAU - Stefanadis, C
AU  - Stefanadis C
LA  - eng
PT  - Journal Article
DEP - 20111231
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 0 (Biomarkers)
RN  - 0 (Receptor for Advanced Glycation End Products)
RN  - 0 (Receptors, Immunologic)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Albuminuria/blood/*etiology/physiopathology/urine
MH  - Analysis of Variance
MH  - Biomarkers/blood
MH  - *Blood Pressure
MH  - Creatinine/blood
MH  - Cross-Sectional Studies
MH  - Disease Progression
MH  - Down-Regulation
MH  - Female
MH  - Humans
MH  - Hypertension/blood/*complications/physiopathology
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Pulse Wave Analysis
MH  - Receptor for Advanced Glycation End Products
MH  - Receptors, Immunologic/*blood
MH  - Risk Assessment
MH  - Risk Factors
MH  - *Vascular Stiffness
EDAT- 2012/01/04 06:00
MHDA- 2013/09/10 06:00
CRDT- 2012/01/04 06:00
PHST- 2011/05/02 00:00 [received]
PHST- 2011/09/19 00:00 [revised]
PHST- 2011/10/02 00:00 [accepted]
PHST- 2012/01/04 06:00 [entrez]
PHST- 2012/01/04 06:00 [pubmed]
PHST- 2013/09/10 06:00 [medline]
AID - S0939-4753(11)00237-7 [pii]
AID - 10.1016/j.numecd.2011.10.003 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2013 Apr;23(4):382-8. doi: 
      10.1016/j.numecd.2011.10.003. Epub 2011 Dec 31.