PMID- 22213066
OWN - NLM
STAT- MEDLINE
DCOM- 20120601
LR  - 20221207
IS  - 1423-0291 (Electronic)
IS  - 1015-2008 (Linking)
VI  - 79
IP  - 2
DP  - 2012
TI  - Altered HLA class I and HLA-G expression is associated with IL-10 expression in 
      patients with cervical cancer.
PG  - 72-83
LID - 10.1159/000334089 [doi]
AB  - Although high-risk human papillomaviruses (HPVs) are an important risk factor in 
      the etiopathogenesis of cervical cancer, increasing evidence suggests that the 
      ability to avoid immune surveillance seems to be linked to the transforming 
      potential of HPV and a rapid progression to cancer. In other cancer models, IL-10 
      contributes to impair anti-tumor immune response either by downregulating human 
      leukocyte antigen Class I (HLA-I) expression or by increasing HLA-G expression. 
      To comprehend how these alterations could contribute to evasion of immune 
      surveillance in cervical cancer, we analyzed HLA-I, HLA-G and IL-10 expressions 
      by immunohistochemistry in 63 biopsies from patients with cervical 
      intraepithelial neoplasia III (CIN-III) and cervical cancer. Immunohistochemistry 
      showed absent or weak HLA-I expression in 50/59 cases. In these cases, a high 
      percentage had loss of heterozygosis. IL-10 and HLA-G expression were observed in 
      46.6 and 27.6% of cases, respectively. Concurrent upregulation of IL-10 was found 
      in 87.5% of HLA-G positive cases (p = 0.000). Similarly, a significant 
      association between IL-10 expression and HLA-I downregulation was found (p = 
      0.028). Finally, we observed higher HLA-G expression in patients with HLA-I 
      downregulation than in those with normal HLA-I expression (p = 0.004). Our 
      results suggest that, in cervical cancer, the IL-10 expression may induce an 
      immunosuppressive environment by upregulating HLA-G expression and downregulating 
      HLA class I expression.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Rodriguez, Josefa Antonia
AU  - Rodriguez JA
AD  - Grupo de Investigacion en Biologia del Cancer, Instituto Nacional de 
      Cancerologia, Bogota, Colombia.
FAU - Galeano, Liliana
AU  - Galeano L
FAU - Palacios, Diana Maria
AU  - Palacios DM
FAU - Gomez, Constanza
AU  - Gomez C
FAU - Serrano, Martha Lucia
AU  - Serrano ML
FAU - Bravo, Maria Mercedes
AU  - Bravo MM
FAU - Combita, Alba Lucia
AU  - Combita AL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111228
PL  - Switzerland
TA  - Pathobiology
JT  - Pathobiology : journal of immunopathology, molecular and cellular biology
JID - 9007504
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Female
MH  - HLA-G Antigens/*metabolism
MH  - Histocompatibility Antigens Class I/immunology/*metabolism
MH  - Humans
MH  - Interleukin-10/*metabolism
MH  - Middle Aged
MH  - Papillomavirus Infections/immunology/virology
MH  - Uterine Cervical Neoplasms/*immunology/pathology/virology
MH  - Uterine Cervical Dysplasia/*immunology/pathology/virology
EDAT- 2012/01/04 06:00
MHDA- 2012/06/02 06:00
CRDT- 2012/01/04 06:00
PHST- 2011/04/28 00:00 [received]
PHST- 2011/09/21 00:00 [accepted]
PHST- 2012/01/04 06:00 [entrez]
PHST- 2012/01/04 06:00 [pubmed]
PHST- 2012/06/02 06:00 [medline]
AID - 000334089 [pii]
AID - 10.1159/000334089 [doi]
PST - ppublish
SO  - Pathobiology. 2012;79(2):72-83. doi: 10.1159/000334089. Epub 2011 Dec 28.