PMID- 22213806
OWN - NLM
STAT- MEDLINE
DCOM- 20120409
LR  - 20220129
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Print)
IS  - 0022-1007 (Linking)
VI  - 209
IP  - 1
DP  - 2012 Jan 16
TI  - Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates 
      IL-10-producing suppressive CD4+ T cells.
PG  - 109-21
LID - 10.1084/jem.20110399 [doi]
AB  - Dendritic cells (DCs) can initiate and shape host immune responses toward either 
      immunity or tolerance by their effects on antigen-specific CD4(+) T cells. 
      DC-asialoglycoprotein receptor (DC-ASGPR), a lectinlike receptor, is a known 
      scavenger receptor. Here, we report that targeting antigens to human DCs via 
      DC-ASGPR, but not lectin-like oxidized-LDL receptor, Dectin-1, or DC-specific 
      ICAM-3-grabbing nonintegrin favors the generation of antigen-specific suppressive 
      CD4(+) T cells that produce interleukin 10 (IL-10). These findings apply to both 
      self- and foreign antigens, as well as memory and naive CD4(+) T cells. The 
      generation of such IL-10-producing CD4(+) T cells requires p38/extracellular 
      signal-regulated kinase phosphorylation and IL-10 induction in DCs. We further 
      demonstrate that immunization of nonhuman primates with antigens fused to 
      anti-DC-ASGPR monoclonal antibody generates antigen-specific CD4(+) T cells that 
      produce IL-10 in vivo. This study provides a new strategy for the establishment 
      of antigen-specific IL-10-producing suppressive T cells in vivo by targeting 
      whole protein antigens to DCs via DC-ASGPR.
FAU - Li, Dapeng
AU  - Li D
AD  - Baylor Institute for Immunology Research, Dallas, TX 75204, USA.
FAU - Romain, Gabrielle
AU  - Romain G
FAU - Flamar, Anne-Laure
AU  - Flamar AL
FAU - Duluc, Dorothee
AU  - Duluc D
FAU - Dullaers, Melissa
AU  - Dullaers M
FAU - Li, Xiao-Hua
AU  - Li XH
FAU - Zurawski, Sandra
AU  - Zurawski S
FAU - Bosquet, Nathalie
AU  - Bosquet N
FAU - Palucka, Anna Karolina
AU  - Palucka AK
FAU - Le Grand, Roger
AU  - Le Grand R
FAU - O'Garra, Anne
AU  - O'Garra A
FAU - Zurawski, Gerard
AU  - Zurawski G
FAU - Banchereau, Jacques
AU  - Banchereau J
FAU - Oh, Sangkon
AU  - Oh S
LA  - eng
GR  - MC_U117565642/MRC_/Medical Research Council/United Kingdom
GR  - U19 AI057234/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120102
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Antigens)
RN  - 0 (Asialoglycoprotein Receptor)
RN  - 0 (Ligands)
RN  - 0 (OLR1 protein, human)
RN  - 0 (Scavenger Receptors, Class E)
RN  - 130068-27-8 (Interleukin-10)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
SB  - IM
MH  - Animals
MH  - Antigens/*immunology/metabolism
MH  - Asialoglycoprotein Receptor/*metabolism
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - Dendritic Cells/*immunology/metabolism
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Humans
MH  - Interleukin-10/*biosynthesis
MH  - Ligands
MH  - Macaca
MH  - Male
MH  - Scavenger Receptors, Class E/metabolism
MH  - Signal Transduction
PMC - PMC3260876
EDAT- 2012/01/04 06:00
MHDA- 2012/04/10 06:00
PMCR- 2012/07/16
CRDT- 2012/01/04 06:00
PHST- 2012/01/04 06:00 [entrez]
PHST- 2012/01/04 06:00 [pubmed]
PHST- 2012/04/10 06:00 [medline]
PHST- 2012/07/16 00:00 [pmc-release]
AID - jem.20110399 [pii]
AID - 20110399 [pii]
AID - 10.1084/jem.20110399 [doi]
PST - ppublish
SO  - J Exp Med. 2012 Jan 16;209(1):109-21. doi: 10.1084/jem.20110399. Epub 2012 Jan 2.