PMID- 22215241
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20221207
IS  - 1432-1459 (Electronic)
IS  - 0340-5354 (Linking)
VI  - 259
IP  - 8
DP  - 2012 Aug
TI  - When is neuromyelitis optica diagnosed after disease onset?
PG  - 1600-5
LID - 10.1007/s00415-011-6384-3 [doi]
AB  - To diagnose neuromyelitis optica (NMO), the 2006 NMO diagnostic criteria is 
      commonly used. However, adequate studies about the time course of NMO according 
      to the criteria have been lacking. The aim of the study was to identify the 
      interval between disease onset and diagnosis of NMO, as well as the clinical 
      characteristics and time course, according to the 2006 NMO diagnostic criteria in 
      Japanese patients with NMO. Clinical progression and time course of 43 Japanese 
      patients with NMO who fulfilled the 2006 NMO diagnostic criteria with mean 
      disease duration of 14.2 years were investigated retrospectively. The initial 
      inflammatory event was myelitis in 44.2% (long extensive transverse myelitis 
      [LETM] in 14.3%), optic neuritis in 41.9%, and concurrent myelitis and optic 
      neuritis in 9.3% of the patients. The presence of LETM and anti-aquaporin-4 
      antibody seropositivity by the end of the observation period was found in 85.7 
      and 93.0% of the patients, respectively. Among the patients whose medical 
      information were sufficiently available, the median intervals between NMO onset 
      and the time until development of both optic neuritis and myelitis, LETM, or 
      fulfillment of the 2006 NMO criteria were 16.5, 35.1, and 27.8 months, 
      respectively. The development of diagnostic method at an early stage of NMO may 
      be needed in order to initiate early treatment.
FAU - Uzawa, Akiyuki
AU  - Uzawa A
AD  - Department of Neurology, Graduate School of Medicine, Chiba University, 1-8-1, 
      Inohana, Chuo-ku, Chiba 260-8670, Japan. a-uzimp1204@umin.ac.jp
FAU - Mori, Masahiro
AU  - Mori M
FAU - Muto, Mayumi
AU  - Muto M
FAU - Masuda, Saeko
AU  - Masuda S
FAU - Kuwabara, Satoshi
AU  - Kuwabara S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120104
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Asian People/*ethnology
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuromyelitis Optica/*diagnosis/*ethnology
MH  - Retrospective Studies
MH  - Time Factors
MH  - Young Adult
EDAT- 2012/01/05 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/01/05 06:00
PHST- 2011/10/07 00:00 [received]
PHST- 2011/12/15 00:00 [accepted]
PHST- 2012/01/05 06:00 [entrez]
PHST- 2012/01/05 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - 10.1007/s00415-011-6384-3 [doi]
PST - ppublish
SO  - J Neurol. 2012 Aug;259(8):1600-5. doi: 10.1007/s00415-011-6384-3. Epub 2012 Jan 
      4.