PMID- 22217471
OWN - NLM
STAT- MEDLINE
DCOM- 20120731
LR  - 20220330
IS  - 1097-6833 (Electronic)
IS  - 0022-3476 (Print)
IS  - 0022-3476 (Linking)
VI  - 160
IP  - 6
DP  - 2012 Jun
TI  - Health-related quality of life in adolescents with or at risk for type 2 diabetes 
      mellitus.
PG  - 911-7
LID - 10.1016/j.jpeds.2011.11.026 [doi]
AB  - OBJECTIVE: To evaluate how adolescents with or at risk for type 2 diabetes 
      mellitus (T2DM) and their parent/guardians (parents) perceive adolescents' 
      health-related quality of life. STUDY DESIGN: We interviewed overweight/obese, 
      12- to 18-year-old youth with T2DM, prediabetes, or insulin resistance and one 
      parent from 5 US sites. Assessments included Pediatric Quality of Life Inventory 
      (PedsQL), Health Utilities Index, family conflict, and diabetes burden. RESULTS: 
      In 108 adolescents, diagnoses included 40.7% with T2DM, 25.0% with prediabetes, 
      and 34.3% with insulin resistance. PedsQL summary score (SS) was higher in 
      adolescents than parents (P=.02). Parents rated physical functioning lower than 
      adolescents (P<.0001), but there were no differences in psychosocial health. 
      Adolescent PedsQL SS did not differ with diagnosis, but was inversely associated 
      with adolescent body mass index z-score (P=.0004) and family conflict (P<.0001) 
      and associated with race/ethnicity (P<.0001). Number of adolescent co-morbidities 
      (P=.007) and burden of diabetes care (P<.05) were inversely associated with 
      parent PedsQL SS. There were no differences in the Health Utilities Index-Mark 3 
      multi-attribute utility score. CONCLUSIONS: Parents perceive their adolescents' 
      physical functioning as more impaired than adolescents themselves. Contextual 
      factors including severity of obesity, race/ethnicity, family conflict, and 
      burden of diabetes care influence health-related quality of life. Family-based 
      approaches to treatment and prevention of T2DM may benefit from increased 
      attention to the biopsychosocial context.
CI  - Copyright (c) 2012 Mosby, Inc. All rights reserved.
FAU - Rhodes, Erinn T
AU  - Rhodes ET
AD  - Division of Endocrinology, Children's Hospital Boston, Boston, MA, USA. 
      Erinn.Rhodes@childrens.harvard.edu
FAU - Goran, Michael I
AU  - Goran MI
FAU - Lieu, Tracy A
AU  - Lieu TA
FAU - Lustig, Robert H
AU  - Lustig RH
FAU - Prosser, Lisa A
AU  - Prosser LA
FAU - Songer, Thomas J
AU  - Songer TJ
FAU - Weigensberg, Marc J
AU  - Weigensberg MJ
FAU - Weinstock, Ruth S
AU  - Weinstock RS
FAU - Gonzalez, Tessa
AU  - Gonzalez T
FAU - Rawluk, Kaitlin
AU  - Rawluk K
FAU - Zoghbi, Roula M
AU  - Zoghbi RM
FAU - Ludwig, David S
AU  - Ludwig DS
FAU - Laffel, Lori M
AU  - Laffel LM
LA  - eng
GR  - K01 DP000089/DP/NCCDPHP CDC HHS/United States
GR  - K24 DK082730/DK/NIDDK NIH HHS/United States
GR  - K24DK082730/DK/NIDDK NIH HHS/United States
GR  - K01DP000089/DP/NCCDPHP CDC HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20120103
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Attitude to Health
MH  - Child
MH  - Diabetes Mellitus, Type 2/epidemiology/*psychology
MH  - Female
MH  - *Health Status
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Prognosis
MH  - Psychometrics/methods
MH  - *Quality of Life
MH  - Risk Assessment/*methods
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - United States/epidemiology
PMC - PMC4793715
MID - NIHMS678319
OID - NLM: HHSPA678319
EDAT- 2012/01/06 06:00
MHDA- 2012/08/01 06:00
PMCR- 2016/03/16
CRDT- 2012/01/06 06:00
PHST- 2011/05/27 00:00 [received]
PHST- 2011/10/04 00:00 [revised]
PHST- 2011/11/10 00:00 [accepted]
PHST- 2012/01/06 06:00 [entrez]
PHST- 2012/01/06 06:00 [pubmed]
PHST- 2012/08/01 06:00 [medline]
PHST- 2016/03/16 00:00 [pmc-release]
AID - S0022-3476(11)01160-7 [pii]
AID - 10.1016/j.jpeds.2011.11.026 [doi]
PST - ppublish
SO  - J Pediatr. 2012 Jun;160(6):911-7. doi: 10.1016/j.jpeds.2011.11.026. Epub 2012 Jan 
      3.