PMID- 22218825
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20141120
IS  - 1432-0711 (Electronic)
IS  - 0932-0067 (Linking)
VI  - 285
IP  - 6
DP  - 2012 Jun
TI  - Positive effects of local therapy with a vaginal lactic acid gel on dysuria and 
      E.coli bacteriuria question our current views on recurrent cystitis.
PG  - 1619-25
LID - 10.1007/s00404-011-2196-z [doi]
AB  - OBJECTIVE: We tested the effect of vaginally applied lactic acid gel on symptoms 
      and bacteriuria in acutely exacerbated recurrent Eschericia coli cystitis. 
      METHODS: Carnoy fixed samples of the morning urine from 20 women with a history 
      of recurrent E.coli cystitis were prospectively investigated for bacteriuria 
      using fluorescence in situ hybridization (FISH). RESULTS: In 11/20 women with 
      acute cystitis, the symptoms and bacteriuria were regressive with lactic acid gel 
      treatment, without the need for antibiotic treatment. The complete regression of 
      symptoms took between 1 week (7 women) and 4 weeks (4 women). In parallel with 
      this regression, the microscopic shape of E.coli bacteria in these women changed 
      from short rods to long curly filaments starting within the first days of 
      therapy. The filamentous transformation affected 100% of the E.coli population in 
      six women and at least 50% of E.coli population in five women and was not 
      observed in urine samples from untreated women or in women without clinical 
      response to lactic acid gel. This could not happen if the bladder was the origin 
      of the infection. CONCLUSIONS: A number of recurrent and probably acute cystitis 
      is a local vagino-urethritis caused by an adhesive invasive E.coli biofilm of the 
      vaginal surface.
FAU - Swidsinski, Alexander
AU  - Swidsinski A
AD  - Polymicrobial Infections and Bacterial Biofilms, Laboratory for Molecular 
      Genetics, CCM, Charite Hospital, Charite Universitatsmedizin Berlin, Campus 
      Mitte, 10098 Berlin, Germany. alexander.swidsinski@charite.de
FAU - Loening-Baucke, Vera
AU  - Loening-Baucke V
FAU - Mendling, Werner
AU  - Mendling W
FAU - Swidsinski, Sonja
AU  - Swidsinski S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120105
PL  - Germany
TA  - Arch Gynecol Obstet
JT  - Archives of gynecology and obstetrics
JID - 8710213
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Gels)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Administration, Intravaginal
MH  - Adult
MH  - Aged
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Cystitis/*drug therapy/microbiology
MH  - Dysuria/drug therapy
MH  - Escherichia coli Infections/*drug therapy
MH  - Female
MH  - Gels/*therapeutic use
MH  - Humans
MH  - Lactic Acid/*therapeutic use
MH  - Middle Aged
MH  - Secondary Prevention
MH  - Vaginal Diseases/*drug therapy/microbiology
EDAT- 2012/01/06 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/01/06 06:00
PHST- 2011/08/25 00:00 [received]
PHST- 2011/12/19 00:00 [accepted]
PHST- 2012/01/06 06:00 [entrez]
PHST- 2012/01/06 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - 10.1007/s00404-011-2196-z [doi]
PST - ppublish
SO  - Arch Gynecol Obstet. 2012 Jun;285(6):1619-25. doi: 10.1007/s00404-011-2196-z. 
      Epub 2012 Jan 5.