PMID- 22218915
OWN - NLM
STAT- MEDLINE
DCOM- 20131203
LR  - 20121017
IS  - 1938-2715 (Electronic)
IS  - 1049-9091 (Linking)
VI  - 29
IP  - 7
DP  - 2012 Nov
TI  - Treatment given near the end of life in castration-resistant prostate cancer.
PG  - 536-40
LID - 10.1177/1049909111433128 [doi]
AB  - Chemotherapy treatment options are limited for patients with castration-resistant 
      prostate cancer (CRPC). The purpose of this study is to report treatment use and 
      adverse effects (AEs) within the last three months of life in patients with CRPC. 
      Of the 88 patients identified, 32% received treatment within 3 months of death, 
      and documented AEs occurred in 25% of patients. Of those, neutropenia (18.3%), 
      nausea/vomiting (18.3%), and febrile neutropenia (13.6%) were the most frequent. 
      Results of this study show high treatment utility towards the end-of-life in 
      patients with CRPC, with one fourth of patients experiencing AEs. Attention to 
      health-related quality of life becomes increasingly important as new treatments 
      appear to have small impact on survival, and AEs of those treatments may 
      significantly impact patient quality of life.
FAU - Zaghloul, Hanna A
AU  - Zaghloul HA
AD  - The Methodist Hospital, Department of Pharmacy, Houston, TX 77030, USA. 
      HAZaghloul@tmhs.org
FAU - Murillo, Jose R Jr
AU  - Murillo JR Jr
LA  - eng
PT  - Journal Article
DEP - 20120104
PL  - United States
TA  - Am J Hosp Palliat Care
JT  - The American journal of hospice & palliative care
JID - 9008229
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Agents/administration & dosage/adverse effects/*therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prostatic Neoplasms/*drug therapy
MH  - *Quality of Life
MH  - Terminal Care/*methods
EDAT- 2012/01/06 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/01/06 06:00
PHST- 2012/01/06 06:00 [entrez]
PHST- 2012/01/06 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 1049909111433128 [pii]
AID - 10.1177/1049909111433128 [doi]
PST - ppublish
SO  - Am J Hosp Palliat Care. 2012 Nov;29(7):536-40. doi: 10.1177/1049909111433128. 
      Epub 2012 Jan 4.