PMID- 22219592
OWN - NLM
STAT- MEDLINE
DCOM- 20120302
LR  - 20220310
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 17
IP  - 48
DP  - 2011 Dec 28
TI  - Impact of liver diseases on the development of type 2 diabetes mellitus.
PG  - 5240-5
LID - 10.3748/wjg.v17.i48.5240 [doi]
AB  - The prevalence of type 2 diabetes mellitus (T2DM) is higher in patients who have 
      liver diseases such as nonalcoholic fatty liver disease, chronic viral hepatitis, 
      hemochromatosis, alcoholic liver disease and cirrhosis. It is suggested that 
      there is a pathogenic link between the presence of T2DM and the severity of liver 
      injury. However, evidence related to the impact of hepatic inflammation on the 
      development of T2DM has not yet emerged. This article provides an overview of the 
      evidence for an increased prevalence of diabetes in a range of liver diseases, 
      the impact of liver diseases on insulin resistance and beta cell dysfunction, and 
      the potential mechanisms whereby coexistent liver diseases exacerbate the 
      development of T2DM.
FAU - Hsieh, Po-Shiuan
AU  - Hsieh PS
FAU - Hsieh, Yen-Ju
AU  - Hsieh YJ
LA  - eng
PT  - Editorial
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Animals
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/epidemiology/*etiology/*physiopathology
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - Insulin-Secreting Cells/physiology
MH  - Liver Diseases/*complications/epidemiology/pathology/*physiopathology
MH  - Reactive Oxygen Species/metabolism
PMC - PMC3247687
OTO - NOTNLM
OT  - Hepatic inflammation
OT  - Insulin resistance
OT  - Type 2 diabetes mellitus
OT  - beta cell dysfunction
EDAT- 2012/01/06 06:00
MHDA- 2012/03/03 06:00
PMCR- 2011/12/28
CRDT- 2012/01/06 06:00
PHST- 2010/09/28 00:00 [received]
PHST- 2011/09/09 00:00 [revised]
PHST- 2011/09/16 00:00 [accepted]
PHST- 2012/01/06 06:00 [entrez]
PHST- 2012/01/06 06:00 [pubmed]
PHST- 2012/03/03 06:00 [medline]
PHST- 2011/12/28 00:00 [pmc-release]
AID - 10.3748/wjg.v17.i48.5240 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2011 Dec 28;17(48):5240-5. doi: 10.3748/wjg.v17.i48.5240.