PMID- 22221108
OWN - NLM
STAT- MEDLINE
DCOM- 20120426
LR  - 20120106
IS  - 2042-7158 (Electronic)
IS  - 0022-3573 (Linking)
VI  - 64
IP  - 2
DP  - 2012 Feb
TI  - Pyeongwee-San extract (KMP6): a new anti-allergic effect.
PG  - 308-16
LID - 10.1111/j.2042-7158.2011.01405.x [doi]
AB  - OBJECTIVES: The prevalence of allergic diseases is increasing due to rapid 
      industrialization and changes in lifestyle. Pyeongwee-San (KMP6) is a traditional 
      Korean medicine that has been used as a basic prescription for digestive 
      disorders. This study investigated the efficacy of KMP6 and its component 
      hesperidin on experimental allergic models. METHODS: The anti-allergic effect of 
      KMP6 was studied against a compound 48/80-induced systemic anaphylactic reaction 
      and the ear swelling response. In addition, a human mast cell line (HMC-1) was 
      used to analyze the activity of histidine decarboxylase. Passive cutaneous 
      anaphylaxis (PCA) from immunoglobulin E (IgE) was used. KEY FINDINGS: KMP6 and 
      hesperidin inhibited the compound 48/80-induced systemic anaphylactic reaction 
      and the ear swelling response as well as histamine release, intracellular calcium 
      levels and tryptase release from rat peritoneal mast cells. KMP6 inhibited 
      histidine decarboxylase activity in stimulated HMC-1 cells and macrophages. In 
      addition, KMP6 inhibited the PCA reaction induced by IgE as well as the levels of 
      IgE, interleukin (IL)-4, IL-5, IL-6 and IL-13 in serum from mice. CONCLUSIONS: 
      These results suggest that KMP6 may exert an anti-allergic effect through not 
      only the inhibition of mast cell degranulation but also the inhibition of 
      histamine synthesis.
CI  - (c) 2011 The Authors. JPP (c) 2011 Royal Pharmaceutical Society.
FAU - Han, Na-Ra
AU  - Han NR
AD  - Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, 
      Seoul, Republic of Korea.
FAU - Kim, Hyung-Min
AU  - Kim HM
FAU - Jeong, Hyun-Ja
AU  - Jeong HJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111118
PL  - England
TA  - J Pharm Pharmacol
JT  - The Journal of pharmacy and pharmacology
JID - 0376363
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Plant Extracts)
RN  - 0 (pyeongwee-san extract)
SB  - IM
MH  - Anaphylaxis/chemically induced
MH  - Animals
MH  - Anti-Allergic Agents/*pharmacology
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Histamine Release/*drug effects/immunology
MH  - Male
MH  - Mast Cells/*drug effects/immunology
MH  - Mice
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2012/01/10 06:00
MHDA- 2012/04/27 06:00
CRDT- 2012/01/07 06:00
PHST- 2012/01/07 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/04/27 06:00 [medline]
AID - 10.1111/j.2042-7158.2011.01405.x [doi]
PST - ppublish
SO  - J Pharm Pharmacol. 2012 Feb;64(2):308-16. doi: 10.1111/j.2042-7158.2011.01405.x. 
      Epub 2011 Nov 18.