PMID- 22221826
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1744-859X (Electronic)
IS  - 1744-859X (Linking)
VI  - 11
IP  - 1
DP  - 2012 Jan 5
TI  - Remission in schizophrenia: results of cross-sectional with 6-month follow-up 
      period and 1-year observational therapeutic studies in an outpatient population.
PG  - 1
LID - 10.1186/1744-859X-11-1 [doi]
AB  - BACKGROUND: A standardized definition of remission criteria in schizophrenia was 
      proposed by the International group of NC Andreasen in 2005 (low symptom 
      threshold for the eight core Positive and Negative Syndrome Scale (PANSS) 
      symptoms for at least 6 consecutive months). METHODS: A cross-sectional study of 
      remission rate, using a 6-month follow-up to assess symptomatic stability, was 
      conducted in two healthcare districts (first and second) of an outpatient 
      psychiatric service in Moscow. The key inclusion criteria were outpatients with 
      an International Classification of Diseases, 10th edition (ICD-10) diagnosis of 
      schizophrenia or schizoaffective disorder. Remission was assessed using modern 
      criteria (severity and time criteria), PANSS and Global Assessment of Functioning 
      (GAF). Patients who were stable but did not satisfied the symptomatic criteria 
      were included in a further 1-year observational study, with the first group 
      (first district) receiving risperidone (long-acting, injectable) (RLAI) and the 
      second group (second district) continuing to receiving routine treatment. 
      Symptoms were assessed with PANSS, social functioning with the personal and 
      social performance scale, compliance with rating of medication influences scale, 
      and extrapyramidal side effects with the Simpson-Angus scale. RESULTS: Only 64 
      (31.5%) of 203 outpatients met the criteria for symptomatic remission in the 
      cross-sectional study, but at the end of the 6-month follow-up period, 158 
      (77.8%) were stable (irrespective of remission status). Among these only 53 
      (26.1%) patients fulfilled the remission criteria. The observational study had 42 
      stable patients in the RLAI group and 35 in the routine treatment group: 19.0% in 
      the RLAI group and 5.7% in the control group met remission criteria after 12 
      months of therapy. Furthermore, reduction of PANSS total and subscale scores, as 
      well as improvement in social functioning, was more significant in the first 
      group. CONCLUSIONS: Only around one-quarter of our outpatient schizophrenic 
      population met full remission criteria. Use of RLAI gave a better remission rate 
      than achieved in standard care with routine treatment. Criteria for remission 
      should take into account clinical course and functioning to support clinical 
      care.
FAU - Mosolov, Sergey N
AU  - Mosolov SN
AD  - Department for Treatment of Mental Disorders, Moscow Research Institute of 
      Psychiatry, Moscow, Russia. profmosolov@mtu-net.ru.
FAU - Potapov, Andrey V
AU  - Potapov AV
FAU - Ushakov, Uriy V
AU  - Ushakov UV
LA  - eng
PT  - Journal Article
DEP - 20120105
PL  - England
TA  - Ann Gen Psychiatry
JT  - Annals of general psychiatry
JID - 101236515
PMC - PMC3278338
EDAT- 2012/01/10 06:00
MHDA- 2012/01/10 06:01
PMCR- 2012/01/05
CRDT- 2012/01/07 06:00
PHST- 2011/09/14 00:00 [received]
PHST- 2012/01/05 00:00 [accepted]
PHST- 2012/01/07 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/01/10 06:01 [medline]
PHST- 2012/01/05 00:00 [pmc-release]
AID - 1744-859X-11-1 [pii]
AID - 10.1186/1744-859X-11-1 [doi]
PST - epublish
SO  - Ann Gen Psychiatry. 2012 Jan 5;11(1):1. doi: 10.1186/1744-859X-11-1.