PMID- 22222492
OWN - NLM
STAT- MEDLINE
DCOM- 20120723
LR  - 20221207
IS  - 1873-5487 (Electronic)
IS  - 0188-4409 (Linking)
VI  - 43
IP  - 1
DP  - 2012 Jan
TI  - Lower serum paraoxonase-1 activity is related to linoleic and docosahexanoic 
      fatty acids in type 2 diabetic patients.
PG  - 75-82
LID - 10.1016/j.arcmed.2011.12.008 [doi]
AB  - BACKGROUND: Serum paraoxonase-1(PON-1) activity is decreased in clinical 
      conditions associated with low high-density lipoprotein cholesterol (HDL-C), 
      increased lipid peroxidation and low-grade chronic inflammation, as in type 2 
      diabetes mellitus (T2DM). Until now there are no data about the association of 
      any fatty acid (FA) with PON-1 activity in T2DM. METHODS: Twenty patients with 
      T2DM and 16 healthy controls were included in this cross-sectional study. Serum 
      PON-1 activity, superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) 
      activity as well as plasma glucose, HbA1c, lipids, high-sensitivity C-reactive 
      protein (hs-CRP) and insulin resistance, homeostasis model assessment (HOMA-IR) 
      were measured. The preparation of FA methyl esters and their gas chromatography 
      (GC) analysis were also performed. RESULTS: HbA1c, plasma insulin, HOMA-IR and 
      triglycerides were higher in patients with T2DM, whereas HDL-C was lower in those 
      subjects. Levels of pro-oxidative enzyme malondialdehyde (MDA) and hs-CRP were 
      significantly higher, and anti-oxidative enzymes SOD and PON-1 activity were 
      decreased in T2DM patients. N-6 PUFAs were higher in T2DM patients, particularly 
      linoleic acid (LA, 18:2 n-6) and arachidonic acid (AA, 20:4 n-6), whereas n-3 
      PUFA, docosahexaenoic acid (DHA, 22:6 n-3) was lower in T2DM patients. Using 
      regression analysis, we have shown that only LA and DHA independently predicted 
      PON-1 activity of all participants, particularly in patients with T2DM. 
      CONCLUSIONS: Decreased serum PON-1 activity may, in part, be influenced by higher 
      levels of LA and lower levels of DHA in patients with T2DM. Prospective, 
      randomized studies are necessary to confirm these preliminary findings.
CI  - Copyright (c) 2012 IMSS. Published by Elsevier Inc. All rights reserved.
FAU - Rasic-Milutinovic, Zorica
AU  - Rasic-Milutinovic Z
AD  - Department of Endocrinology, University Clinical Center Zemun/Belgrade, Faculty 
      of Medicine, University of Belgrade, Serbia. zoricar@eunet.rs
FAU - Popovic, Tamara
AU  - Popovic T
FAU - Perunicic-Pekovic, Gordana
AU  - Perunicic-Pekovic G
FAU - Arsic, Aleksandra
AU  - Arsic A
FAU - Borozan, Suncica
AU  - Borozan S
FAU - Glibetic, Marija
AU  - Glibetic M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120102
PL  - United States
TA  - Arch Med Res
JT  - Archives of medical research
JID - 9312706
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (Phospholipids)
RN  - 0 (Triglycerides)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - 9KJL21T0QJ (Linoleic Acid)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 3.1.8.1 (Aryldialkylphosphatase)
RN  - EC 3.1.8.1 (PON1 protein, human)
SB  - IM
MH  - Adult
MH  - Aryldialkylphosphatase/*blood
MH  - Biomarkers/blood
MH  - Blood Glucose
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/enzymology
MH  - Docosahexaenoic Acids/*blood
MH  - Female
MH  - Glutathione Peroxidase/blood
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Insulin/blood
MH  - Linear Models
MH  - Linoleic Acid/*blood
MH  - Male
MH  - Middle Aged
MH  - Phospholipids/blood
MH  - Superoxide Dismutase/blood
MH  - Triglycerides/blood
EDAT- 2012/01/10 06:00
MHDA- 2012/07/24 06:00
CRDT- 2012/01/07 06:00
PHST- 2011/09/03 00:00 [received]
PHST- 2011/12/21 00:00 [accepted]
PHST- 2012/01/07 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/07/24 06:00 [medline]
AID - S0188-4409(11)00300-6 [pii]
AID - 10.1016/j.arcmed.2011.12.008 [doi]
PST - ppublish
SO  - Arch Med Res. 2012 Jan;43(1):75-82. doi: 10.1016/j.arcmed.2011.12.008. Epub 2012 
      Jan 2.