PMID- 22222676
OWN - NLM
STAT- MEDLINE
DCOM- 20120611
LR  - 20211021
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 120
IP  - 1
DP  - 2012 Jan
TI  - Circulating levels of persistent organic pollutants (POPs) and carotid 
      atherosclerosis in the elderly.
PG  - 38-43
LID - 10.1289/ehp.1103563 [doi]
AB  - BACKGROUND AND OBJECTIVE: Increased circulating levels of persistent organic 
      pollutants (POPs) have been associated with myocardial infarction. Because 
      myocardial infarction is an atherosclerotic disease, we investigated, in a 
      cross-sectional study, whether POP levels are related to atherosclerosis. 
      METHODS: In the population-based Prospective Investigation of the Vasculature in 
      Uppsala Seniors (PIVUS) study (n = 1,016 participants 70 years of age), the 
      prevalence of carotid artery plaques was determined by ultrasound. The number of 
      carotid arteries with plaques (0, 1, or 2) was recorded. Also, the intima-media 
      thickness (IMT) and gray scale median of the intima-media complex (IM-GSM) were 
      measured. Twenty-three POPs, comprising 16 polychlorinated biphenyls (PCBs), 5 
      pesticides, 1 dioxin, and 1 brominated compound (brominated diphenyl ether 
      congener BDE-47), were analyzed by high-resolution chromatography coupled to 
      high-resolution mass spectrometry. RESULTS: Seven of the POPs (PCB congeners 153, 
      156, 157, 170, 180, 206, and 209) were significantly associated with the number 
      of carotid arteries with plaques even after adjusting for multiple risk factors 
      (sex, waist circumference, body mass index, fasting blood glucose, systolic and 
      diastolic blood pressure, high-density lipoprotein and low-density lipoprotein 
      cholesterol, serum triglycerides, smoking, antihypertensive treatment, and statin 
      use; p = 0.002-0.0001). Highly chlorinated PCBs (congeners 194, 206, and 209) 
      were associated with an echolucent IM-GSM (p < 0.0001 after adjustment), whereas 
      associations between POPs and IMT were modest. CONCLUSIONS: Circulating levels of 
      PCBs were associated with atherosclerotic plaques and echogenicity of the 
      intima-media complex independent of cardiovascular risk factors, including 
      lipids. This suggests that POPs may be a risk factor for myocardial infarction, 
      but associations need to be confirmed in prospective studies.
FAU - Lind, P Monica
AU  - Lind PM
AD  - Occupational and Environmental Medicine, Department of Medicine, Uppsala 
      University, Uppsala, Sweden. monica.lind@medsci.uu.se
FAU - van Bavel, Bert
AU  - van Bavel B
FAU - Salihovic, Samira
AU  - Salihovic S
FAU - Lind, Lars
AU  - Lind L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
CIN - Environ Health Perspect. 2012 Jan;120(1):A34. PMID: 22214554
MH  - Aged
MH  - Atherosclerosis/*blood/diagnostic imaging/epidemiology
MH  - Carotid Arteries/diagnostic imaging
MH  - Carotid Artery Diseases/*blood/diagnostic imaging/epidemiology
MH  - Cross-Sectional Studies
MH  - Dioxins/blood
MH  - Environmental Pollutants/*blood
MH  - Halogenated Diphenyl Ethers/blood
MH  - Humans
MH  - Myocardial Infarction/blood
MH  - Pesticides/blood
MH  - Polychlorinated Biphenyls/blood
MH  - Prevalence
MH  - Risk Factors
MH  - Ultrasonography
PMC - PMC3261941
COIS- The authors declare they have no actual or potential competing financial 
      interests.
EDAT- 2012/01/10 06:00
MHDA- 2012/06/12 06:00
PMCR- 2012/01/01
CRDT- 2012/01/07 06:00
PHST- 2011/02/11 00:00 [received]
PHST- 2011/10/03 00:00 [accepted]
PHST- 2012/01/07 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/06/12 06:00 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - ehp.1103563 [pii]
AID - 10.1289/ehp.1103563 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2012 Jan;120(1):38-43. doi: 10.1289/ehp.1103563.