PMID- 22222815
OWN - NLM
STAT- MEDLINE
DCOM- 20120611
LR  - 20120727
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 73
IP  - 3
DP  - 2012 Mar
TI  - Association of polymorphisms in the promoter region of FCER1A gene with atopic 
      dermatitis, chronic uticaria, asthma, and serum immunoglobulin E levels in a Han 
      Chinese population.
PG  - 301-5
LID - 10.1016/j.humimm.2011.12.001 [doi]
AB  - The high-affinity receptor for immunoglobulin E (IgE) plays a central role in 
      allergy diseases. Previous studies have reported the association of variants in 
      the proximal promoter of FCER1A with IgE levels as well as allergy disorders. 
      Another promoter gene polymorphism that is located upstream of exon 1 has not 
      been investigated. We investigated the association of variants in the promoter 
      located upstream of FCER1A exon 1 with serum IgE levels and allergy diseases in a 
      Han Chinese population. A total of 97 patients with atopic dermatitis (AD), 123 
      patients with chronic urticaria (CU), 286 children with asthma, and control 
      groups were screened for polymorphisms in the promoter region located upstream of 
      FCER1A exon 1 by the polymerase chain reaction-ligation detection reaction 
      method. Total serum IgE levels were tested in groups. The rare allele A of the 
      rs2427837 A/G polymorphism was significantly different in the AD group compared 
      with the controls. No association with the polymorphism was observed in the CU 
      group. In asthmatic patients, IgE levels were higher in the mutation genotypes GA 
      of rs2427837 and TC of rs2251746 compared with normal genotype individuals. The 
      minor allele of rs2427837 and rs2251746 in FCER1A is a genetic risk factor of 
      high IgE levels.
CI  - Copyright A(c) 2012 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Zhou, Juan
AU  - Zhou J
AD  - Department of Laboratory Medicine, Shanghai First People's Hospital, Shanghai 
      Jiaotong University, Shanghai, People's Republic of China. zhou_20090601@126.com
FAU - Zhou, Ying
AU  - Zhou Y
FAU - Lin, Li-hui
AU  - Lin LH
FAU - Wang, Juan
AU  - Wang J
FAU - Peng, Xia
AU  - Peng X
FAU - Li, Jia
AU  - Li J
FAU - Li, Li
AU  - Li L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111211
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (FCER1A protein, human)
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
EIN - Hum Immunol. 2012 Jun;73(6):692
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asthma/blood/*genetics/immunology
MH  - Child
MH  - China
MH  - Chronic Disease
MH  - Dermatitis, Atopic/blood/*genetics/immunology
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Promoter Regions, Genetic/genetics
MH  - Receptors, IgE/genetics/immunology/*metabolism
MH  - Urticaria/blood/*genetics/immunology
MH  - Young Adult
EDAT- 2012/01/10 06:00
MHDA- 2012/06/12 06:00
CRDT- 2012/01/07 06:00
PHST- 2011/06/14 00:00 [received]
PHST- 2011/11/12 00:00 [revised]
PHST- 2011/12/01 00:00 [accepted]
PHST- 2012/01/07 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/06/12 06:00 [medline]
AID - S0198-8859(11)00585-4 [pii]
AID - 10.1016/j.humimm.2011.12.001 [doi]
PST - ppublish
SO  - Hum Immunol. 2012 Mar;73(3):301-5. doi: 10.1016/j.humimm.2011.12.001. Epub 2011 
      Dec 11.