PMID- 22222969
OWN - NLM
STAT- MEDLINE
DCOM- 20130123
LR  - 20220331
IS  - 1347-4715 (Electronic)
IS  - 1342-078X (Print)
IS  - 1342-078X (Linking)
VI  - 17
IP  - 5
DP  - 2012 Sep
TI  - Failure to detect significant association between estrogen receptor-alpha gene 
      polymorphisms and endometriosis in Japanese women.
PG  - 423-8
LID - 10.1007/s12199-011-0259-1 [doi]
AB  - OBJECTIVES: The aim of the study was to test whether estrogen receptor 1 (ESR1) 
      gene polymorphisms are correlated with the risk of the development of 
      endometriosis in Japanese women, as a preliminary study. METHODS: To compare 
      allelic frequencies and genotype distributions, a case-control study of 100 
      affected women and 143 women with no evidence of disease was performed using 10 
      microsatellite repeat markers and 66 single-nucleotide polymorphisms (SNPs) in 
      the ESR1 gene region. RESULTS: Although our results might be insufficient to 
      detect genetic susceptibility, owing to the small sample size and low genetic 
      power, statistical analysis of the differences in allelic frequency between the 
      cases and controls at each microsatellite locus demonstrated that no 
      microsatellite locus in the ESR1 gene displayed a significant association with 
      the disease when multiple testing was taken into account. Also, there were no 
      statistically significant differences in the SNP allele frequencies and genotypes 
      between the cases and controls when multiple testing was taken into account. 
      CONCLUSION: The findings in our pilot study suggest that ESR1 polymorphisms do 
      not contribute to endometriosis susceptibility.
FAU - Matsuzaka, Yasunari
AU  - Matsuzaka Y
AD  - Division of Basic Molecular Science and Molecular Medicine, School of Medicine, 
      Tokai University, Bohseidai, Isehara, Kanagawa, Japan. 
      yasunari.matsuzaka@helmholtz-muenchen.de
FAU - Kikuti, Yukie Y
AU  - Kikuti YY
FAU - Izumi, Shun-ichiro
AU  - Izumi S
FAU - Goya, Kenichi
AU  - Goya K
FAU - Suzuki, Takahiro
AU  - Suzuki T
FAU - Cai, Li-yi
AU  - Cai LY
FAU - Oka, Akira
AU  - Oka A
FAU - Inoko, Hidetoshi
AU  - Inoko H
FAU - Kulski, Jerzy K
AU  - Kulski JK
FAU - Kimura, Minoru
AU  - Kimura M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120106
PL  - Japan
TA  - Environ Health Prev Med
JT  - Environmental health and preventive medicine
JID - 9609642
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Endometriosis/epidemiology/*genetics
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/epidemiology
MH  - Humans
MH  - Japan/epidemiology
MH  - Microsatellite Repeats
MH  - Middle Aged
MH  - Pilot Projects
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
PMC - PMC3437353
EDAT- 2012/01/10 06:00
MHDA- 2013/01/24 06:00
PMCR- 2013/09/01
CRDT- 2012/01/07 06:00
PHST- 2011/08/23 00:00 [received]
PHST- 2011/11/29 00:00 [accepted]
PHST- 2012/01/07 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2013/01/24 06:00 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - 259 [pii]
AID - 10.1007/s12199-011-0259-1 [doi]
PST - ppublish
SO  - Environ Health Prev Med. 2012 Sep;17(5):423-8. doi: 10.1007/s12199-011-0259-1. 
      Epub 2012 Jan 6.