PMID- 22224635
OWN - NLM
STAT- MEDLINE
DCOM- 20121022
LR  - 20160511
IS  - 1945-0257 (Electronic)
IS  - 1945-0257 (Linking)
VI  - 16
IP  - 6
DP  - 2012 Jun
TI  - Inflammatory bowel disease: susceptibility and disease heterogeneity revealed by 
      human leukocyte antigen genotyping.
PG  - 482-7
LID - 10.1089/gtmb.2011.0132 [doi]
AB  - This study aimed to investigate the association between HLA DR/DQ and 
      inflammatory bowel diseases (IBD) in Tunisian patients and to determine the 
      relationship between HLA DR/DQ alleles with the clinical disease patterns. DNA 
      typing of human leukocyte antigen (HLA) genes was performed in 70 ulcerative 
      colitis (UC) patients, 40 Crohn's disease (CD) patients, and 123 healthy controls 
      (HC) using a polymerase chain reaction sequence specific primer technique. Data 
      were analyzed using Cochran-Mantel-Haenszel test and binary logistic regression. 
      Compared with HC, IBD patients showed an increased frequency of the homozygous 
      DRB1*07 genotype. This positive association was maintained when UC and CD were 
      separately compared to HC. In UC patients, DQB1*03:02 was predictive of colonic 
      extension whereas DRB1*13 and DQB1*03:01 were associated limited disease 
      localization (left-sided colitis and proctitis). The DRB1*15 allele increased in 
      patients with extraintestinal manifestations. In CD, female patients showed an 
      increased frequency of DRB1*13, DRB1*15, and DQB1*06 alleles and DRB1*13-DQB1*06 
      haplotype, whereas a significant increase of DRB1*07, DQB1*02 alleles, and 
      DRB1*07-DQB1*02 haplotype was noted in male patients. These results show a 
      significant association of the homozygous HLA-DRB1*07 genotype with UC and CD and 
      of several HLA DR/DQ alleles and haplotypes with the clinical phenotypes of these 
      diseases in Tunisian patients. Because of limited statistical power, our study 
      findings are subject to further investigation.
FAU - Bouzid, Dorra
AU  - Bouzid D
AD  - Immunology Department, Habib Bourguiba Hospital, Sfax, Tunisia. 
      dorra-ing@voila.fr
FAU - Kammoun, Arwa
AU  - Kammoun A
FAU - Amouri, Ali
AU  - Amouri A
FAU - Mahfoudh, Nadia
AU  - Mahfoudh N
FAU - Haddouk, Samy
AU  - Haddouk S
FAU - Tahri, Nabil
AU  - Tahri N
FAU - Makni, Hafedh
AU  - Makni H
FAU - Masmoudi, Hatem
AU  - Masmoudi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120106
PL  - United States
TA  - Genet Test Mol Biomarkers
JT  - Genetic testing and molecular biomarkers
JID - 101494210
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Colitis, Ulcerative/*genetics/immunology/physiopathology
MH  - Crohn Disease/*genetics/immunology/physiopathology
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics/immunology
MH  - HLA-DR Antigens/*genetics/immunology
MH  - HLA-DRB1 Chains/genetics
MH  - Haplotypes
MH  - Histocompatibility Antigens Class II/genetics/immunology
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Inflammatory Bowel Diseases/*genetics/immunology/*physiopathology
MH  - Male
MH  - Phenotype
MH  - Tunisia
EDAT- 2012/01/10 06:00
MHDA- 2012/10/23 06:00
CRDT- 2012/01/10 06:00
PHST- 2012/01/10 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/10/23 06:00 [medline]
AID - 10.1089/gtmb.2011.0132 [doi]
PST - ppublish
SO  - Genet Test Mol Biomarkers. 2012 Jun;16(6):482-7. doi: 10.1089/gtmb.2011.0132. 
      Epub 2012 Jan 6.