PMID- 22226770
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20191210
IS  - 1873-2550 (Electronic)
IS  - 0304-4017 (Linking)
VI  - 187
IP  - 1-2
DP  - 2012 Jun 8
TI  - Pomegranate enriched diet enhances the hematology, innate immune response, and 
      disease resistance in olive flounder against Philasterides dicentrarchi.
PG  - 147-56
LID - 10.1016/j.vetpar.2011.12.006 [doi]
AB  - Olive flounder, Paralichythys olivaceus fed with pomegranate enriched diet and 
      challenged with or without Philasterides dicentrarchi had a significantly higher 
      white blood cell (WBC) count on weeks 2 and 4 than the infected group fed with 
      non enriched diet (standard diet). Similarly the red blood cell (RBC) counts did 
      not significantly change in control and treated fish on weeks 1 and 2. It was 
      significantly increased in treated fish on week 2 when compared to the control. 
      In both the groups the hemoglobin (Hb) and hematocrit (Ht) levels significantly 
      increased on weeks 2 and 4. The mean corpuscular volume (MCV) did not 
      significantly change at any time in both groups whereas mean corpuscular 
      hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) increased 
      significantly on week 4 in the treated group. The leukocytes such as lymphocytes 
      (Lym), monocytes (Mon), neutrophils (Neu), and biochemical parameters such as 
      total protein (TP), glucose (GLU), and calcium (CAL) levels significantly 
      increased in treated groups on week 2 or 4 as compared to the control. The 
      scuticocidal activity and respiratory burst activity were significantly enhanced 
      in treated groups with or without parasite on weeks 2-4. However, the serum 
      lysozyme activity was significantly enhanced from weeks 1 to 4. The protective 
      response in terms of cumulative mortality was low in groups fed with enriched 
      diet against parasite when compared to control. Therefore, we suggest that 
      pomegranate enriched diet following challenge with P. dicentrarchi restores the 
      altered hematological and biochemical parameters, and improves the innate immune 
      system in olive flounder against P. dicentrarchi.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Harikrishnan, Ramasamy
AU  - Harikrishnan R
AD  - Marine Applied Microbes and Aquatic Organism Disease Control Lab, Department of 
      Aquatic Biomedical Sciences, School of Marine Biomedical Sciences & Marine and 
      Environmental Research Institute, Jeju National University, Jeju 690-756, South 
      Korea. rhari123@yahoo.com
FAU - Kim, Ju-Sang
AU  - Kim JS
FAU - Kim, Man-Chul
AU  - Kim MC
FAU - Balasundaram, Chellam
AU  - Balasundaram C
FAU - Heo, Moon-Soo
AU  - Heo MS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111219
PL  - Netherlands
TA  - Vet Parasitol
JT  - Veterinary parasitology
JID - 7602745
RN  - 0 (Hemoglobins)
RN  - 11062-77-4 (Superoxides)
SB  - IM
MH  - Animal Feed/*analysis
MH  - Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Ciliophora/*classification
MH  - Ciliophora Infections/prevention & control/veterinary
MH  - Diet/*veterinary
MH  - Dietary Supplements
MH  - Erythrocyte Count
MH  - Fish Diseases/parasitology/*prevention & control
MH  - *Flounder
MH  - Hematocrit
MH  - Hemoglobins
MH  - Immunity, Innate/drug effects
MH  - Leukocyte Count
MH  - *Lythraceae
MH  - Superoxides/metabolism
MH  - Time Factors
EDAT- 2012/01/10 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/01/10 06:00
PHST- 2011/04/04 00:00 [received]
PHST- 2011/12/01 00:00 [revised]
PHST- 2011/12/13 00:00 [accepted]
PHST- 2012/01/10 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - S0304-4017(11)00844-2 [pii]
AID - 10.1016/j.vetpar.2011.12.006 [doi]
PST - ppublish
SO  - Vet Parasitol. 2012 Jun 8;187(1-2):147-56. doi: 10.1016/j.vetpar.2011.12.006. 
      Epub 2011 Dec 19.