PMID- 22226842
OWN - NLM
STAT- MEDLINE
DCOM- 20120625
LR  - 20151119
IS  - 1872-9754 (Electronic)
IS  - 0197-0186 (Linking)
VI  - 60
IP  - 3
DP  - 2012 Feb
TI  - Tau protein is involved in morphological plasticity in hippocampal neurons in 
      response to BDNF.
PG  - 233-42
LID - 10.1016/j.neuint.2011.12.013 [doi]
AB  - Tau protein, a microtubule-associated protein involved in a number of 
      neurological disorders such as Alzheimer's disease (AD), may undergo 
      modifications under both physiological and pathological conditions. However, the 
      signaling pathways that couple tau protein to neuronal physiology such as 
      synaptic plasticity have not yet been elucidated. Here we report that tau protein 
      is involved in morphological plasticity in response to brain derived neurotrophic 
      factor (BDNF). Stimulation of the cultured rat hippocampal neurons with BDNF 
      resulted in increased tau protein expression, as detected by Western blotting. 
      Furthermore, tau protein accumulated in the distal region of the neurite when 
      treated with taxol or taxol plus BDNF. The increased tau protein also protected 
      neurons against nocodazole-induced dendrite loss. Moreover, BDNF promoted spine 
      growth as well as tau protein over-expression. Knockdown of tau protein using 
      specific short-hairpin RNA (shRNA) significantly decreased the spine density. And 
      BDNF could not increase the spine density of tau-knockdown neurons. These results 
      highlight a possible role for tau protein in the dynamic rearrangement of 
      cytoskeletal fibers vital for BDNF-induced synaptic plasticity.
CI  - Copyright A(c) 2011 Elsevier Ltd. All rights reserved.
FAU - Chen, Qian
AU  - Chen Q
AD  - Key Laboratory of Medical Protection for Electromagnetic Radiation Ministry of 
      Education, Department of Occupational Health, Third Military Medical University, 
      Chongqing 400038, China.
FAU - Zhou, Zhou
AU  - Zhou Z
FAU - Zhang, Lei
AU  - Zhang L
FAU - Wang, Yuan
AU  - Wang Y
FAU - Zhang, Yan-wen
AU  - Zhang YW
FAU - Zhong, Min
AU  - Zhong M
FAU - Xu, Shang-cheng
AU  - Xu SC
FAU - Chen, Chun-hai
AU  - Chen CH
FAU - Li, Li
AU  - Li L
FAU - Yu, Zheng-ping
AU  - Yu ZP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111231
PL  - England
TA  - Neurochem Int
JT  - Neurochemistry international
JID - 8006959
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (tau Proteins)
RN  - P88XT4IS4D (Paclitaxel)
RN  - SH1WY3R615 (Nocodazole)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/pharmacology
MH  - Antineoplastic Agents, Phytogenic/pharmacology
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Cells, Cultured
MH  - Dendritic Spines/drug effects/ultrastructure
MH  - Fluorescent Antibody Technique
MH  - Gene Silencing/drug effects
MH  - Hippocampus/*cytology/*drug effects
MH  - Immunohistochemistry
MH  - Neurites/drug effects/ultrastructure
MH  - Neuronal Plasticity/*drug effects
MH  - Neurons/*drug effects/*ultrastructure
MH  - Nocodazole/pharmacology
MH  - Paclitaxel/pharmacology
MH  - Phosphorylation
MH  - Plasmids/genetics
MH  - RNA, Small Interfering/pharmacology
MH  - Rats
MH  - Real-Time Polymerase Chain Reaction
MH  - Transfection
MH  - tau Proteins/genetics/*physiology
EDAT- 2012/01/10 06:00
MHDA- 2012/06/26 06:00
CRDT- 2012/01/10 06:00
PHST- 2011/08/08 00:00 [received]
PHST- 2011/12/05 00:00 [revised]
PHST- 2011/12/22 00:00 [accepted]
PHST- 2012/01/10 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/06/26 06:00 [medline]
AID - S0197-0186(11)00406-2 [pii]
AID - 10.1016/j.neuint.2011.12.013 [doi]
PST - ppublish
SO  - Neurochem Int. 2012 Feb;60(3):233-42. doi: 10.1016/j.neuint.2011.12.013. Epub 
      2011 Dec 31.