PMID- 22227290
OWN - NLM
STAT- MEDLINE
DCOM- 20121108
LR  - 20221207
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 37
IP  - 1
DP  - 2012 Apr 27
TI  - Association between TNF-alpha promoter -308A/G polymorphism and tardive dyskinesian 
      Chinese Han patients with schizophrenia.
PG  - 106-10
LID - 10.1016/j.pnpbp.2011.12.007 [doi]
AB  - OBJECTIVE: Previous studies have indicated that the immune may be involved in the 
      pathogenesis of tardive dyskinesia (TD). Some genetic polymorphisms in the human 
      leukocyte antigen (HLA) I and II regions have been associated with TD, and the 
      tumor necrosis factor-alpha (TNF-alpha) gene is located in the HLA III region. TNF-alpha 
      levels in the striatum significantly increased in haloperidol-induced TD in rats. 
      The TNF-alpha gene -308A/G single nucleotide polymorphism (SNP) has been shown to 
      directly influence TNF-alpha expression. The genetic association between the TNF-alpha 
      gene -308A/G SNP and TD is unclear. The present study investigated whether this 
      variation is associated with clinical phenotypes and TD in schizophrenia in a 
      genetically homogeneous northern Chinese Han population. METHODS: We genotyped 
      the TNF-alpha gene -308A/G SNP in patients with schizophrenia with TD (n=350) and 
      without TD (n=410). The Abnormal Involuntary Movement Scale (AIMS) and Positive 
      and Negative Syndrome Scale (PANSS) were used to assess the severity of TD and 
      psychopathology of schizophrenia, respectively. RESULTS: The allele and genotype 
      frequencies did not significantly differ between patients with schizophrenia with 
      and without TD (p>0.05). No significant difference was found in the total AIMS 
      score between the genotypes (p>0.05). However, the PANSS negative symptom 
      subscore was associated with risk for TD (p=0.004), and a significant difference 
      was found in total AIMS score between the genotypes in TD patients (p=0.013). 
      CONCLUSION: The TNF-alpha gene -308A/G polymorphism does not appear to play a major 
      role in the susceptibility to TD in patients with schizophrenia in a northern 
      Chinese Han population. However this polymorphism may play a role in the TD 
      severity.
CI  - Copyright A(c) 2011 Elsevier Inc. All rights reserved.
FAU - Wang, Fan
AU  - Wang F
AD  - National Institute on Drug Dependence, Peking University, Beijing, 100191, China.
FAU - Fan, Hongzhen
AU  - Fan H
FAU - Sun, Hongqiang
AU  - Sun H
FAU - Yang, Fude
AU  - Yang F
FAU - Luo, Yixiao
AU  - Luo Y
FAU - Liu, Haibo
AU  - Liu H
FAU - Kosten, Thomas R
AU  - Kosten TR
FAU - Lu, Lin
AU  - Lu L
FAU - Zhang, Xiang Yang
AU  - Zhang XY
LA  - eng
GR  - K05-DA0454/DA/NIDA NIH HHS/United States
GR  - P50-DA18827/DA/NIDA NIH HHS/United States
GR  - U01-MH79639/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20111229
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 5Z93L87A1R (Guanine)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - Adenosine/genetics
MH  - Adult
MH  - Aged
MH  - Asian People/ethnology/*genetics
MH  - Female
MH  - Genetic Association Studies/methods
MH  - Guanine/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Movement Disorders/diagnosis/ethnology/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Promoter Regions, Genetic/*genetics
MH  - Schizophrenia/diagnosis/ethnology/*genetics
MH  - Single-Blind Method
MH  - Surveys and Questionnaires
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2012/01/10 06:00
MHDA- 2012/11/09 06:00
CRDT- 2012/01/10 06:00
PHST- 2011/10/08 00:00 [received]
PHST- 2011/12/09 00:00 [revised]
PHST- 2011/12/20 00:00 [accepted]
PHST- 2012/01/10 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/11/09 06:00 [medline]
AID - S0278-5846(11)00372-1 [pii]
AID - 10.1016/j.pnpbp.2011.12.007 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2012 Apr 27;37(1):106-10. doi: 
      10.1016/j.pnpbp.2011.12.007. Epub 2011 Dec 29.